摘要
用葡聚糖-活性炭单点饱和分析法测定35例正常卵巢组织,75例良性病变及49例恶性卵巢组织的胞浆雌激素受体(ER)和孕激素受体(PR)。结果表明,恶性病变中,性腺间质类和上皮性恶性肿瘤,其ER、PR含量均高于生殖细胞来源的和转移性癌(ER:P<0.05,PR:P<0.025);上皮性恶性肿瘤中,内膜样癌的ER和PR含量高于桨液性、粘液性及透明细胞癌(ER:P<0.05,PR:P<0.01)。提示受体含量高者有用内分泌治疗的可能和推测有较好的预后。卵巢恶性肿瘤组织ER和PR含量与患者月经状况,临床分期及肿瘤的分化程度均无明显关联。
Ovarian specimens from 159 different patients were analyzed for estrogen andprogesterone receptor (ER and PR) contentwith the Dextran-coated Charcoal method. The results indicated that the contents of ER and PR in malignant ovarian tumors were not correlated with the menstrual cy-cle of the patient, clinical and differ-entiation of the tumor.Among malignant ovarian tumors, the mean ER and PR con-centrations in sex-cord stromal tumors andendometrioid carcinomas were higher than those in other malignant ovarian tumors(P<0.05, P<0.025). This suggests the pos-sibility of endocrine therapy for these pa-tients with the hope for a better prognosis.
出处
《华西医科大学学报》
CAS
CSCD
1989年第3期253-255,共3页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
关键词
卵巢肿瘤
雌激素受体
孕激素受体
Ovarian tumor
Estrogen receptor
Progesterone receptor
Dextran-coated Charcoal single-point-saturable analysis
