摘要
目的分析研究妊娠合并下生殖道人乳头瘤病毒(HPV)感染对妊娠结局和新生儿的近期影响。方法选取2013年6月至2014年6月确诊并接受治疗的60例妊娠合并下生殖道人乳头瘤病毒感染患者为试验组,另选取同一时间段经HPV检测为阴性的60例健康孕妇为对照组。两组研究对象分别在分娩时抽取羊水、胎盘组织、胎儿脐静脉血等进行生殖道人乳头瘤病毒检测,研究生殖道HPV对妊娠结局及新生儿产生的影响。同时观察两种分娩方式下新生儿羊水、胎盘、脐血以及咽部或外阴分泌物的生殖道HPV感染情况。结果试验组患者自然分娩率略高于对照组的自然分娩率,但差异无统计学意义(P>0.05)。试验组患者终止妊娠、稽留流产、胎儿畸形、早产、产后出血、胎膜早破、产褥感染以及胎儿生长受限发生率与对照组相比,差异无统计学意义(P>0.05)。试验组患者自然分娩的新生儿发羊水HPV阳性率、胎盘HPV阳性率、脐血HPV阳性率以及咽部或外阴分泌物HPV阳性率与剖宫产新生儿相比,差异无统计学意义(P>0.05)。结论妊娠合并下生殖道HPV感染对妊娠结局和新生儿造成的影响并不大,但仍需采取措施对孕妇进行治疗,避免新生儿发生感染。
Objective To analyze the influence of human papilloma virus（ HPV） infection in lower genital tract on the outcome of pregnancy and newborns. Methods A total of 60 cases of pregnancy complicated with lower genital tract human papilloma virus infection during June2013 to June 2014 were allocated in trial group,and 60 healthy pregnant women without HPV infection at the same period were selected as control group,and their amniotic fluid,placenta,fetal umbilical vein blood during delivery were detected for HPV infection in these 2 groups,and simultaneously the effect of human papilloma virus infection on the outcome of pregnancy and newborns had been observed. Results The natural birth rate（ 46. 67%） in patients of trial group was slightly higher than that（ 43. 33%） of control group,but the difference was not statistically significant（ P〉0. 05）. The difference in termination of pregnancy,missed abortion,fetal malformation,premature delivery,postpartum hemorrhage,premature rupture of membrane,puerperal infection and restriction of fetal growth in patients of trial group compared with those of control group was not statistically significant（ P〉0. 05）. In the trial group,natural childbirth,neonatal hair HPV positive rate and HPV positive rate in amniotic fluid,placenta and cord blood and positive rates of HPV in pharynx or vulva secretion compared with those of newborns by cesarean section,and the difference was not statistically significant（ P〉0. 05）. Conclusion The influence of human papilloma virus（ HPV） genital tract infection on outcome of pregnancy and newborns is not significant,but it still needs to take measures for treatment of pregnant women infected with HPV in order to prevent the transmission of infection to newborns.
出处
《临床和实验医学杂志》
2016年第1期72-74,共3页
Journal of Clinical and Experimental Medicine
