摘要
目的:了解南宁地区儿童呼吸道感染苛养菌分布及耐药性特点。方法:对2013年8月至2014年7月在广西壮族自治区妇幼保健院住院的呼吸道感染患儿5 235例痰标本苛养菌培养及药敏结果进行回顾分析。结果:5 235例标本共分离出肺炎链球菌226株、流感嗜血杆菌126株、副流感嗜血杆菌34株和卡他布兰汉菌21株。肺炎链球菌对万古霉素均敏感,对喹诺酮类、青霉素、氯霉素、头孢菌素类、酶抑制剂类抗菌药物较敏感,对阿奇霉素、复方磺胺甲唑、红霉素、克林霉素、四环素耐药率超过90%。流感嗜血杆菌、副流感嗜血杆菌、卡他布兰汉菌对头孢噻肟、阿莫西林/克拉维酸、亚胺培南敏感,对氨曲南耐药率均超过60%。流感嗜血杆菌、副流感嗜血杆菌、卡他布兰汉菌产β-内酰胺酶检出率分别为40.48%、38.24%和61.90%(P<0.05)。结论:儿童呼吸道感染苛养菌以肺炎链球菌为主,有其独特耐药谱,临床应明确病原学诊断,根据药敏结果选用敏感抗菌药物。
Objective： To investigate the distribution and drug resistance of fastidious bacteria of children with respiratory tract infection in Nanning area. Methods： Culture and drug sensitivity results of fastidious bacteria were analysed retrospectively in 5,235 children with respiratory tract infection. Results： Among the 5,235 samples,Streptococcus pneumonia（ 226 cases）,Haemophilus influenza（ 126cases）,Haemophilus parainfluenzae（ 34 cases） and Moraxelle catarrhalis（ 21 cases） were identified. No Streptococcus pneumoniae showed resistant to vancomycin,and sensitivity to quinolone,penicillin,chloramphenicol,cephalosporins and enzyme inhibitors,but resistant to azithromycin, compound sulfamethoxazole, erythromycin, clindamycin, and tetracycline（ above 90%）. Haemophilus influenza,Haemophilus parainfluenzae and Moraxelle catarrhalis were sensitivity to cefotaxime, amoxicillin / clavulanic acid and imipenem,and resistant to aztreonam（ above 60%）. The rates of ESBLs production of Haemophilus influenza, Haemophilus parainfluenzae and Moraxelle catarrhalis were 40. 48%,38. 24% and 61. 90% respectively（ P〈0. 05）. Conclusion： Streptococcus pneumonia is the main fastidious bacteria in children with respiratory tract infection,and the drug resistant was unique. Etiology diagnosis should be performed. Antibiotic should be used according to the results of antibiotic sensitive test.
出处
《儿科药学杂志》
CAS
2016年第1期46-48,共3页
Journal of Pediatric Pharmacy
关键词
儿童
呼吸道感染
苛养菌
耐药性
children
respiratory tract infections
fastidous bacteria
drug resistance
