摘要
目的研究中国人群ABCG2 rs2231142基因多态性与高尿酸血症相关性研究。方法入组高尿酸血症组161例,正常组1068例,收集人群的生化指标并采用问卷调查收集饮食生活习惯等环境因素。采用Taqman探针技术对研究对象进行基因分型,采用逻辑回归模型分析基因多态性,并分析基因-环境与高尿酸血症相关性。结果风险等位基因T是高尿酸血症的风险等位基因(P<0.01);患有高血压病的男性风险等位基因携带者高尿酸血症的发病风险增加(P<0.05);女性风险等位基因携带者在吸烟人群或服用阿司匹林人群中,高尿酸血症的发病风险也增高(P<0.05)。结论 ABCG2 rs2231142基因多态性与高尿酸血症有明显的相关性,是高尿酸血症的风险基因,且在部分环境因素作用下易感人群高尿酸血症发病风险明显增高。
Objective To investigate the correlation between ABCG2 rs2231142 genetic polymorphisms and serum UA levels in Chinese population. Methods A total of 161 patients in hyperuricemia group and 1068 normal patients in control group were recruited in this study. Blood sample were tested and lifestyle information were collected by questionnaires. All the subjects were genotyped by Taqman assay. The association between genetic polymorphisms and gene-environment interactions were analyzed by logical regression model. Results The variant of ABCG2 rs2231142 had the strongest association with hyperuricemia（ P 0. 01）. The risk of hyperuricemia was increased in the male T alleles carrier with hypertension（ P 0. 05） and there was a great increased risk of hyperuricemia in the female subjects who was used to smoking or taking Asprin（ P 0. 05）. Conclusion The genetic variant rs2231142 in ABCG2 shows highly significant association with hyperuricemia in Chinese population,and this association is strongly modified by environment factors.
出处
《实用临床医药杂志》
CAS
2015年第24期12-16,共5页
Journal of Clinical Medicine in Practice
关键词
尿酸
基因多态性
高尿酸血症
uric acid
genetic polymorphism
hyperuricemia
