摘要
目的探讨雌激素受体(ER)、孕激素受体(PR)和波形蛋白(Vim)在子宫内膜癌中的表达特点及临床意义。方法采用免疫组织化学Envision法检测46例子宫内膜癌病例中ER、PR和Vim蛋白的表达。结果1子宫内膜癌ER、PR、Vim的阳性表达率分别为72%、78%、76%。2ER阳性表达与肌层浸润深度呈负相关(r=-0.397,P=0.006)。3PR阳性表达率在子宫内膜样腺癌与其他组织学类型子宫内膜癌中差异有统计学意义,在发病年龄<60岁与≥60岁病例组间差异也有统计学意义(P值均<0.05)。PR阳性表达与组织学分级呈负相关(r=-0.344,P=0.019)。4Vim阳性表达与组织学分级呈正相关(r=0.316,P=0.033)。5经Spearman等级相关分析,ER与PR阳性表达呈正相关(r=0.372,P=0.011)。结论 ER、PR和Vim与子宫内膜癌发展的恶性程度相关,其在表达上的差异与肿瘤生物学行为有一定关系,子宫内膜癌在进展过程中,ER与PR可能有协同作用。
Objective To investigate the expression of estrogen receptor（ER）,progesterone receptor（PR）and vimentin（Vim）in endometrial carcinoma and their clinical importance.Methods The expressions of ER,PR and Vim in 46 cases with endometrial carcinoma were tested by immunohistochemistry Envision method and correlated with clinicopathologic features.Results 1The positive expression rates of ER,PR and Vim in endometrial carcinoma were 72%,78% and 76%,respectively.2The positive expression of ER and the depth of myometrial invasion were negatively correlated（r=-0.397,P =0.006）.3The positive expression rates of PR in endometrioid carcinoma and other histological types of endometrial carcinoma were significantly different,and there was also a significant difference in the onset age of60years and ≥60years groups（P〈0.05,respectively）.The positive expression of PR was decreased with histological grade raised（r=-0.344,P =0.019）.4The positive expression of Vim was positively related with increase of histological grade raised（r=0.316,P =0.033）.5By Spearman correlation analysis,ER and PR expressions in endometrial carcinoma were positively correlated（r=0.372,P =0.011）.Conclusion ER,PR and Vim are related to the malignancy degree of endometrial carcinoma,and their expression differences may have some relationship with tumor biological behavior.ER may exert a coordinating function together with PR in the progression of endometrial carcinoma.
出处
《山西医药杂志》
CAS
2015年第24期2843-2846,共4页
Shanxi Medical Journal
基金
国家自然科学基金青年项目(81202045)
