摘要
目的了解以头颅包块起病的儿童B淋巴母细胞淋巴瘤的临床、病理、影像学特点及其疗效、预后。方法对6例患儿资料进行临床病例分析及文献复习。结果 6例患儿均以头颅包块起病,早期无其他伴随症状,最终依靠病理活检确诊为B淋巴母细胞淋巴瘤,就诊时1例临床分期为Ⅲ期,其余5例临床分期为Ⅳ期。按改良的BFM-95-LBL方案化疗,中位随访时间45（31-57）个月,均持续完全缓解。结论头颅包块是B淋巴母细胞淋巴瘤的特殊临床表现,疾病早期容易误诊,怀疑本病应尽早进行病理活检以明确诊断,确诊后按B淋巴母细胞淋巴瘤方案正规化疗,预后良好。
Objective To study clinical,pathological and imaging characteristics as well as prognosis of precursor B-cell lymphoblastic lymphoma originated from skull in children.Methods Six children with precursor B-cell lymphoblastic lymphoma originated from skull in clinically analyzed and related literatures were reviewed.Results The onset of the disease started with skull masses in all the 6children no other symptom was found in the early phase.Diagnoses with precursor B-cell lymphoblastic lymphoma were made via pathological biopsy.Among these patients,1 case was in clinical stage HI and others were in stage Ⅳ.All the patients have received chemotherapy based on modified BFM-95-LBL protocol.A median of 45 months（31-57 months） follow up revealed that all the patients were in continuous complete remission.Conclusions Skull mass is a special clinical manifestation for precursor B-cell lymphoblastic lymphoma,which is prone to be misdiagnosed in the early stages.Therefore,pathological biopsy should be performed as soon as possible when suspected.This disease is associated with good prognosis after conventional chemotherapy.
出处
《中国小儿血液与肿瘤杂志》
CAS
2015年第6期308-311,共4页
Journal of China Pediatric Blood and Cancer
关键词
B淋巴母细胞淋巴瘤
头颅包块
儿童
Precursor B-cell lymphoblastic lymphoma
Skull mass
Children
