摘要
目的探讨通窍活血汤加减治疗脑梗死急性期的临床疗效及对血液流变学的影响。方法 59例脑梗死急性期患者随机分为观察组30例和对照组29例,对照组采用西医常规治疗,观察组在对照组治疗基础上给予通窍活血汤加减,疗程为15 d。比较2组临床疗效、中医证候疗效,治疗前后2组神经功能缺损(NIHSS)评分、日常生活能力(ADL)评分及血液流变学的变化。结果治疗后,观察组总有效率为96.67%显著高于对照组的72.41%(P<0.05),中医证候总有效率(93.33%)有高于对照组(79.31%)的趋势,但差异无统计学意义(P>0.05);2组NIHSS评分较治疗前明显减少,而ADL评分明显增加(P<0.01),其中观察组减少及增加幅度均大于对照组(P<0.05或P<0.01);2组血液流变学各指标均较治疗前有所改善(P<0.05或P<0.01),观察组在改善血浆比黏度、红细胞压积和纤维蛋白原方面明显优于对照组(P<0.05)。结论通窍活血汤加减能有效改善脑梗死急性期患者的神经功能缺损及血液流变学相关指标,且疗效显著。
Objective To explore the influence of modified Tongqiao Huoxue decoction on clinical efficacy and hemorheology in the treatment of patients with acute cerebral infarction （ACI）. Methods A total of 59 ACI patients were randomly divided into observation group （30 cases） and control group （29 cases）. Control group was treated with routine western therapy, while observa- tion group with modified Tongqiao Huoxue decoction based on the treatment of control group, 15 d as a cycle. Clinical efficacy and traditional Chinese medicine （TCM） syndromes as well as changes of national institutes of health stroke scale （NIHSS）, activity of daily living （ADL） and hemorheology before and after treatment were compared between two groups. Results After treatment, the total effective rate was 96.67 % in observation group, evidently higher than the 72.41% in control group （P〈0.05）, whereas the total effective rate of TCM syndrome was 93.33% in observation group, higher than the 79.31% in control group, but there was no significant difference （P 〉 0.05）. NIHSS score decreased markedly in both group while ADL score increased prominently than treat- ment before （P 〈 0.05 or P 〈 0.01）, which changed more significantly in observation group than in control group （P 〈 0.05 or P 〈 0.01 ）. Hemorheologic indexes were improved apparently in both groups than treatment before, and observation group was obviously better than control group in im- proving plasma viscosity, hematocrit and fibrinogen （P 〈 0.05）. Conclusion Modified Tongqiao Huoxue decoction can effectively improve relevant indexes of NIHSS and hemorheology with signifi- cant clinical efficacy.
出处
《实用临床医药杂志》
CAS
2015年第23期15-17,27,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11521512)
关键词
脑梗死
通窍活血汤
疏血通注射液
血液流变学
cerebral infarction
Tongqiao Huoxue decoction
Shuxuetong lnjection
hemorheology
