摘要
生物钟是地球上绝大多数生物经过长期演化形成的一种内在机制,可以调控生物的生理、代谢和行为的节律,以适应地球因自转而产生的近24小时的昼夜周期。人类在空间探索过程中由于环境因素与地表环境的巨大差异,生理和健康面临很大的压力。在诸多环境因子中,重力变化对生物钟具有重要的影响。迄今人们已对人及多种生物在微重力环境中的变化规律进行了研究,但微重力调控生物钟的分子机制仍很不清楚。现将对此方面的研究概况和进展进行综述。
The internal circadian clocks have been evolved in the vast majority of life forms on the Earth, which allow organisms to synchronize their physiology, metabolism and behavior to ca. 24-h periodic changes in environment factors caused by the Earth self-rotation. The distinct differences in environmental factors in space bring about remarkable challenges for space exploration, which dramatically influences physiology, metabolism and behavior of the astronauts. Amongst numerous environmental factors, alteration in gravity has considerable impacts on a lot of physiological variables including circadian rhythms. Though many studies have shed light on changes of the circadian clock in humans and other species under microgravity, the underlying molecular mechanism is largely unclear. Here we review advances regarding the impacts of microgravity on circadian clocks.
出处
《生命科学》
CSCD
2015年第11期1433-1440,共8页
Chinese Bulletin of Life Sciences
基金
国家重点基础研究发展计划(“973”项目)(2011CB711000)
国家重大科学研究计划(2012CB947603)
教育部新世纪优秀人才计划(NCET-12-0566)
国家自然科学基金项目(31171119,31071122)
关键词
生物钟
微重力
空间探索
circadian clock
microgravity
space exploration
