摘要
目的：分析南寒水石的生药学性状,为该药材的临床安全用药提供参考。方法：收集南寒水石样品,按性状特征分类并描述,并对其原矿石磨片进行显微鉴定;采用乙二胺四乙酸二钠滴定法测定样品中CaCO3含量;利用X射线衍射（XRD）对样品主要物相进行分析;采用电感耦合等离子体发射光谱仪（ICP-OES）测定样品中微量元素含量。结果：根据形态将所收集到的样品分为3类,岩石类型均为方解石大理石,样品中CaCO3质量分数88.90%97.08%。9批样品中有3批样品中重金属及有害元素总量超标,主要表现为As和Hg超标,其中As有6批超标,Cd有1批超标,Hg有6批超标。结论：暂定南寒水石中CaCO3含量不得低于92%。仅有Ⅰ类寒水石达到《药用植物及制剂进出口绿色行业标准》中有害元素的限量要求,为确保南寒水石的安全使用及制定合理的质量标准奠定基础。
Objective： To provide references for clinical medication safety of Calcitum by analyzing its pharmacgnosical properties. Method： Calcitum samples were collected and its species was classified and identified by macroscopic identification,and its ore stone mill piece was identified by microscopic identification. The content of CaCO3 in Calcitum were measured by ethylenediamine tetraacetic acid disodium salt titration method. Main phase and mineral elements content were assayed and calculated by X-ray power diffraction（ XRD） and inductively coupled plasma optical spectrometer（ ICP-OES）. Result： Though identification of morphology, samples were divided into 3 groups and rock types were identified as calcite marble. The mass fraction of CaCO3 was between88. 90%-97. 08% in samples. It was found that there were three batches of samples with higher of heavy metals and harmful elements which mainly were As and Hg in nine batches of samples than limits. Among all samples,six batches of samples with higher of As,one batch of samples with higher of Cd and six batches of samples with higher of Hg than limits. Conclusion： According to these results,the content of CaCO3 in Calcitum shall not be less than 92%. Analysis of elements shows that only Calcitum Ⅰ reached the standard of Medicinal Plants and Preparations for the Green Trade Standard,it can lay foundation for safe use and quality evaluation of Calcitum.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第24期65-68,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
四川省科技支撑计划项目(2012SZ0119)
