摘要
目的观察并比较培美曲塞与吉西他滨联合顺铂一线治疗晚期肺腺癌的疗效和安全性。方法将病理学检查确诊的肺腺癌患者352例分为培美曲塞组（n=196）和吉西他滨组（n=156）。培美曲塞组患者给予培美曲塞500 mg·m-2静脉滴注,第1天;顺铂20 mg·m-2,第1~5天。吉西他滨组患者给予吉西他滨1 000 mg·m-2静脉滴注,第1、8天;顺铂20 mg·m-2,第1~5天。21 d为1个治疗周期,2组患者均给予2个治疗周期。评价2组患者疗效及药物安全性。结果培美曲塞组患者部分缓解（PR）46例,疾病稳定（SD）90例,疾病进展（PD）60例,治疗有效率为69.4%（136/196例）;吉西他滨组患者PR 23例,SD 38例,PD 95例,治疗有效率为39.1%。培美曲塞组患者治疗有效率显著高于吉西他滨组（P〈0.05）。培美曲塞组患者白细胞、中性粒细胞及血小板减少发生率均显著低于吉西他滨组（P〈0.05）。结论培美曲塞联合顺铂治疗晚期肺腺癌疗效优于吉西他滨联合顺铂,且培美曲塞联合顺铂不良反应少,安全性更高。
Objective To observe and compare the efficacy and safety of pemetrexed or gemcitabine combined with cisplatin in the treatment of patients with advanced adenocarcinoma of lung. Methods A total of 352 patients with advanced adenocarcinoma of lung diagnosed pathologically were divided into pemetrexed group（ n = 196） and gemcitabine group（ n = 156）.The patients in pemetrexed group were given pemetrexed 500 mg·m- 2on the first day and cisplatin 20 mg·m- 2on the first to fifth day. The patients in gemcitabine group were given gemcitabine 1 000 mg·m- 2on the first and eighth day,and cisplatin20 mg·m- 2on the first to fifth day. Each patient was given two cycles at least. The chemotherapy was repeated every 21 days.And the efficacy and drug safety were evaluated. Results In pemetrexed group,the case number of partial response（ PR）,stable disease（ SD） and progressive disease（ PD） was 46,90 and 60,respectively,which was 23,38 and 95 in gemcitabine group,respectively. The effective power of pemetrexed group（ 69. 4%） was significantly higher than that of gemcitabine group（ 39. 1%）（ P〈0. 05）. The incidence rates of white blood cell,neutrophilic granulocyte and platelet decreasing in pemetrexed group were significantly lower than those in gemcitabine group（ P〈0. 05）. Conclusion The efficacy of pemetrexed in combination with cisplatin is better than that of gemcitabine in combination with cisplatin in the treatment of patients with advanced adenocarcinoma of lung,which has minorer response and higher safety.
出处
《新乡医学院学报》
CAS
2015年第12期1103-1105,共3页
Journal of Xinxiang Medical University
关键词
肺腺癌
培美曲塞
吉西他滨
顺铂
adenocarcinoma of lung
pemetrexed
gemcitabine
cisplatin
