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Linking, thinking & fixing:the story about the 2015 Chemistry Nobel Prize and the future of science 被引量:2

Linking, thinking & fixing:the story about the 2015 Chemistry Nobel Prize and the future of science
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摘要 Did you know there are roughly over 10,000 DNA damages in a cell per day?Do not be too alarmed though,thanks to various vital DNA repair mechanisms we are able to continue function normally as an organism and maintain our genome integrity.It is no wonder then why this year prestigious Chemistry Nobel Prize(s)went to Drs.Thomas Lindahl,Aziz Sancar,and Paul Modrich for their Did you know there are roughly over 10,000 DNA dam- ages in a cell per day? Do not be too alarmed though, thanks to various vital DNA repair mechanisms we are able to continue function normally as an organism and maintain our genome integrity. It is no wonder then why this year prestigious Chemistry Nobel Prize(s) went to Drs.
出处 《Science Bulletin》 SCIE EI CAS CSCD 2015年第23期2071-2076,共6页 科学通报(英文版)
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  • 1Lindahl T (2013) My journey to DNA repair. Genomics Proteomics Bioinformatics 11:2-7.
  • 2Lindahl T (1993) Instability and decay of the primary structure of DNA. Nature 362:709-715.
  • 3Sancar A (1996) DNA excision repair. Annu Rev Biochem 65:43-81.
  • 4Sancar A, Lindsey-Boltz LA, ~Jnsal-Kaqmaz K et al (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39-85.
  • 5Modrich P, Lahue R (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem 65:101-133.
  • 6Modrich P (1994) Mismatch repair, genetic stability, and cancer. Science 266:1959-1960.
  • 7Helleday T, Petermann E, Lundin C et al (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8:193-204.
  • 8McKinnon PJ (2009) DNA repair deficiency and neurological disease. Nat Rev Neurosci 10:100-112.

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