摘要
目的探讨右美托咪啶在椎管内麻醉中的临床辅助效果。方法收集我院2013年1月至2015年4月收治的下肢手术行蛛网膜下腔或硬膜外麻醉患者50例前瞻性研究且随机分为两组，每组25例，对照组患者麻醉成功后静脉泵注生理盐水，实验组患者则静脉泵注有美托咪啶，比较两组患者不同阶段听觉诱发电位指数（AAI）值情况、Ramsay镇静评分情况与不良反应情况等。结果实验组患者在T1与T4时期AAI值显著性低于对照组，差异有统计学意义（P〈0．01）；两组患者在T0、T2与T3时期AAI值比较差异无统计学意义（P〉0．05）；实验组患者在T1、T2、T3与T4时期Ramsay镇静评分均显著性高于对照组，两组比较差异具有统计学意义（P〈0．01）；实验组患者恶心、呕吐、躁动、呼吸抑制与心动过缓发生率明显低于对照组，差异有统计学意义（P〈0．05）。结论有美托咪啶在椎管内麻醉中的临床辅助效果显著，镇痛效果稳定，可提升镇静效果，安全性较好，具有借鉴性。
Objective To investigate the clinical auxiliary effect of dexmedetomidine in spinal anesthesia. Methods 50 patients admitted in our hospital from January 2013 to April 2015 for lower limb surgery with subarachnoid anesthesia or epidural anesthesia were selected for prospective study, and randomly divided into two groups with 25 cases in each group. After anesthetized successfully, patients in control group were given intravenous pumping of normal saline, while patients in experimental group were given intravenous pumping of dexmedetomidine. AAI, Ramsay sedation score and adverse reactions of two groups at different stages were compared. Results AAI of experimental group at T1, T4 were significantly lower than those of control group （P〈0.01）, there were no statistically significant differences in AAI at T0, T2, T3 between two groups （P〉0.05）. Ramsay sedation score of experimental group at T1, T2, T3, T4 were significantly higher than those of control group, with statistically significant differences between two groups （P〈0.01）. The incidences of nausea, emesis, dysphoria, respiratory depression, bradycardia of experimental group were significantly lower than those of control group, with statistically significant differences between two groups （P〈0.05）. Conclusion Dexmedetomidine has significant clinical auxiliary effect in spinal anesthesia, with stable sedation effect and good safety, therefore it is of referentiability.
出处
《国际医药卫生导报》
2015年第24期3632-3634,共3页
International Medicine and Health Guidance News
