摘要
目的了解医院感染耐亚胺培南不动杆菌的危险因素和Ⅰ类整合子流行情况,为防控医院感染耐亚胺培南不动杆菌提供参考依据。方法对医院感染耐亚胺培南不动杆菌菌株进行耐药性分析及多因素研究,对Ⅰ类整合子基因进行聚合酶链式反应(PCR)检测。结果入住重症监护室(ICU)、联合使用抗菌药物和急性生理及慢性健康状况评分Ⅱ(APACHEⅡ)高是医院感染耐亚胺培南不动杆菌的独立危险因素,Ⅰ类整合子阳性率高达98.6%。结论医院感染耐亚胺培南不动杆菌受多种因素影响,Ⅰ类整合子在该院广泛流行,与耐亚胺培南不动杆菌的多重耐药性相关,应加强重症患者感染防御措施,及时发现、控制感染源,保护易感人群,切断播散途径。
Objective To investigate the risk factors of nosocomial infection of imipenem-resistant Acinetobacter and prevalence situation of classⅠintegron to provide references for preventing and controlling its nosocomial infection.Methods The strains of imipenem-resistant Acinetobacter causing nosocomial infection were performed the drug resistance analysis and multivariate research.The classⅠintegron gene was detected by using PCR.Results Admission to ICU,joint use of antibacterial agents and high APACHEⅡscore were the independent risk factors of nosocomial infection induced by imipenem resistant Acinetobacter.The positive rate of classⅠintegron was up to 98.6%.Conclusion The nosocomial infection of imipenem-resistant Acinetobacter is affected by multiple factors.The classⅠintegron is widely prevalent in this hospital,which is associated with the multidrug resistance of imipenem-resistant Acinetobacter.The infection prevention measures in severe patients should be strengthened for timely finding the infection source,protecting the susceptible populations and cutting off dissemination approach.
出处
《国际检验医学杂志》
CAS
2015年第23期3365-3366,共2页
International Journal of Laboratory Medicine
基金
国家自然基金资助项目(81201253)
江苏省昆山市社会科学技术发展基金项目(KS1011)
关键词
医院感染
耐亚胺培南不动杆菌
危险因素
Ⅰ类整合子
nosocomial infection
imipenem-resistant Acinetobacter
risk factor
classⅠintegron
