摘要
目的从受者筛选、术式选择、预后、生活质量、并发症改善等方面对胰肾联合移植治疗糖尿病做一简明介绍及展望。方法通过查阅并筛选国内外相关文献,归纳总结有关胰肾联合移植在治疗糖尿病方面的效果、现状、预后及最新进展。结果胰肾联合移植作为一种成熟的糖尿病合并终末期肾病的治疗方案,目前已在全球各大移植中心开展,其疗效确切,副作用可控,术后患者生活质量改善明显,但有关移植患者的筛选、移植术式的选择、术后免疫抑制药物的应用方案等目前各中心并不完全一致。结论胰肾联合移植是1型糖尿病终末期肾病患者最有效的治疗方式,它为稳定的胰岛素分泌提供了一种可行的、更合乎生理的途径。尽管移植涉及到很大的外科手术并且有不小的风险,胰肾联合移植还是显著提高了患者的生存率,改善了患者的生活质量,并且减少了糖尿病相关并发症的发生。基于以上原因,胰肾联合移植应该被作为所有符合条件患者的首选治疗手段。
Objective To do a brief introduction and prospects for simultaneous pancreas and kidney transplanta- tion from aspects of recipient screening, choice of operative method, prognosis, quality of life, and complications. Method Domestic and international literatures were collected to summary the effect, prognosis, and the latest progress of simultaneous pancreas and kidney transplantation in the treatment of diabetes. Results As a kind of mature treatment of diabetic with end-stage renal disease, simultaneous pancreas and kidney transplantation had been carried out in most transplantation centers around the world, it had the definite therapeutic effect and controllable side effects, the life quality of posttransplantation patients would be improved notably. However, the screen of transplantation patient, the selection of transplantation operation, and the postoperative immunosuppressive protocols had not yet been reached a consensus. Conclusions Simultaneous pancreas and kidney transplantation is the most effective treatment for type 1 diabetes patients with end-stage renal disease, it provides a more feasible and more physiological way for the secretion of insulin. Although the patient has to undergo a major operation and take some risk, simultaneous pancreas and kidney transplantation still improves the patient＇s survival rate and the quality of life, and reduces the incidence of complications related to diabetes. Based on the above reasons, simultaneous pancreas and kidney transplantation should be a preferred treatment for all eligible patients.
出处
《中国普外基础与临床杂志》
CAS
2015年第12期1535-1542,共8页
Chinese Journal of Bases and Clinics In General Surgery
关键词
糖尿病
胰肾联合移植
历史
现状
展望
Diabetes
Simultaneous pancreas and kidney transplantation
History
Current situation
Prospect
