期刊文献+

胃癌的分子靶向治疗现状

原文传递
导出
摘要 我国为胃癌高发区,发病率居全球第2位,死亡率居国内恶性肿瘤的第3位[1]。70%胃癌患者发现时已是晚期,化学治疗(化疗)是转移性胃癌的主要治疗手段,尽管肿瘤学家们一直不懈地努力,化疗后晚期胃癌中位生存时间仅11个月左右[2]。因此突破化疗的瓶颈,寻找更为有效且作用机制不同的分子靶向药物,是胃癌的重要研究方向。
出处 《内科理论与实践》 2015年第5期339-344,共6页 Journal of Internal Medicine Concepts & Practice
  • 相关文献

参考文献24

  • 1胃癌诊疗规范(2011年版)[J].中国医学前沿杂志(电子版),2012,4(5):62-71. 被引量:249
  • 2Waddell T, Chau I, Cunningham D, et al. Epirubicin, ox- aliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesopha- gogastric cancer (REAL3): a randomised, open-label phase 3 trial[J]. Lancet Oncol, 14(6): 481-489.
  • 3Janjigian YY, Werner D, Pauligk C, et al. Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: a European and USA International col- laborative analysis[J]. Ann Oncol, 2012, 23(10): 2656- 2662.
  • 4Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive ad- vanced gastric or gastro-oesophageal junction cancer (To- GA): a phase 3, open-label, randomised controlled trial [J]. Lancet, 2010, 376(9742): 687-697.
  • 5Satoh T, Xu RH, Chung HC, et al. Lapatinib plus pacli- taxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase HI study[J]. J Clin Oncol, 2014, 32(19): 2039-2049.
  • 6Hecht JR, Bang YJ, Qin S, et al. Lapatinib in combina- tion with capecitabine plus oxaliplatin (CapeOx) in HER2-positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma (AC)[J]. J Clin Oncol. 2013, 31(18 Suool): LBA4001.
  • 7Janjigian YY, Ku GY, Ilson DH, et al. A phase II study of afatinib in patients (pts) with metastatic human epidermal growth factor receptor (HER2)-positive trastuzumab re- fractory esophagogastric (EG) cancer[J]. J Clin Oncol, 2015, 33(3 Suppl): 59.
  • 8Barok M, Tanner M, Ktininki K, et al. Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer[J]. Cancer Lett, 2011, 306(2): 171-179.
  • 9Lordick F, Kang YK, Chung HC, et al. Capecitabine and cisplatin with or without cetuximab for patients with pre- viously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial[J]. Lancet Oncol, 2013, 14(6): 490-499.
  • 10Du F, Zheng Z, Shi S, et al. S-1 and cisplatin with or without nimotuzumab for patients with untreated unre- sectable or metastatic gastric cancer: a randomized, open- label phase 2 trial[J]. Medicine (Baltimore), 2015, 94(23): E958.

共引文献248

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部