摘要
背景:组织工程支架能够营造适当的神经再生微环境,富集神经再生所需的营养因子,促进轴突生长。目的:综述近年来组织工程材料在神经损伤修复方面的科研进展。方法:应用计算机检索Pub Med数据库2009至2014年关于组织工程材料修复神经损伤的文章,检索词为"nerve regeneration,prostheses and implants",并限定为"Full text"。同时利用计算机检索中国知网数据库2004至2014年相关方面的文章,检索词为"神经修复,材料"。结果与结论:目前用于神经损伤的支架材料主要有天然材料、天然衍生材料、合成材料与复合材料,不同种材料具备各自的优点与缺点。通过化学交联剂或化学修饰,将天然衍生聚合物与其他天然或合成材料复合,可提高其理化和生物学特性,即复合材料神经支架取得的神经再生效果比单一材料效果好,因此当前的研究热点是复合材料。在临床研究方面,胶原蛋白基的神经修复支架材料已开始进入临床研究阶段。
BACKGROUND： Tissue engineering scaffolds can create proper nerve regeneration microenvironment,enrich nutritional factors for nerve regeneration and promote axonal growth. OBJECTIVE： To review the progress of tissue engineering scaffolds in nerve repair in recent years. METHODS： A computer-based retrieval was performed to search full-text articles addressing tissue engineering scaffolds used to repair nerve damage published from 2009 to 2014 in Pub Med databases using the keywords of ＂nerve regeneration,prostheses and implants＂ as well as articles published from 2004 to 2014 in CNKI database using the keywords of ＂nerve repair,material＂ in Chinese. RESULTS AND CONCLUSION： Currently,scaffold materials for nerve damage mainly include natural materials,naturally derived materials,synthetic materials and composites,all of which have their own advantages and disadvantages. By chemical crosslinkers or chemical modification,the naturally derived polymer can be combined with other natural or synthetic composite materials,to improve their physicochemical and biological properties,i.e.,the composite scaffolds have better effects than single materials in nerve regeneration. Therefore the current research focus is composite materials. In clinical research,collagen scaffold for nerve repair has entered the clinical research stage.
出处
《中国组织工程研究》
CAS
北大核心
2015年第43期7035-7040,共6页
Chinese Journal of Tissue Engineering Research
基金
中国科学院战略性先导项目课题(XDA01030504
XDA01030503)~~
