摘要
干细胞在恶性肿瘤中的应用受到越来越多的研究与探讨。间充质干细胞具有天然免疫豁免特性、向肿瘤细胞迁移的能力、多系分化的潜能,使其成为抗肿瘤的一种生物制剂。在肿瘤生长微环境下,间充质干细胞具有双重作用:促肿瘤形成和抗肿瘤形成。哪种作用占优势,取决于间充质干细胞的类型及来源,肿瘤细胞的类型,干细胞与机体免疫细胞、癌细胞的相互作用等。间充质干细胞分泌的肿瘤坏死因子相关凋亡诱导配体具有促进肿瘤细胞凋亡的作用。脐带组织来源的间充质干细胞与癌细胞共培养,可促进干细胞表达该配体,具有抗肿瘤作用。对间充质干细胞的促肿瘤形成和抗肿瘤形成的特性进行综述。
Stem cell treatments are being increasingly explored for their possible potential to treat variouscancers. Mesenchymal stem cells are believed to possess anti-tumor potential and are preferred for theirproperties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineagedifferentiation. This tumor tropism property of MSCs could be utilized to deliver anti-tumor biological agents tothe site of tumor. In a tumor micro-environment, MSCs are believed to play both, a pro-tumorigenic and an anti-tumorigenic role. However, this is dependent on a host of factors like, types of MSCs, its source, type of cancercell line under investigation, interactions between MSCs, host＇s immune cells and cancer cells. Among severalcytokines secreted by MSCs, TRAIL （Tumor necrosis factor related apoptosis inducing ligand） are reported to bepro-apoptotic for tumor cells. Umbilical cord tissue derived MSCs are believed to regulate TRAIL expressionin MSC-cancer cell co-culture system resulting in induction of apoptosis in cancer cells. We present a reviewconcerning on pro-tumorigenic and anti-tumorigenic properties of MSCs based on different studies reporting.
出处
《医学研究与教育》
CAS
2015年第5期93-97,共5页
Medical Research and Education
关键词
间充质干细胞
肿瘤
趋向性
抗癌
mesenchymal stem cells
tumor
tropism
anti-cancer
