活血化瘀方联合纤溶酶治疗急性下肢深静脉血栓形成被引量：8

Combined therapy of Huoxuehuayu recipe with fibrinolysis enzyme on lower extremity deep venous thrombosis

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摘要目的观察活血化瘀方联合纤溶酶治疗急性下肢深静脉血栓形成(LEDVT)的临床疗效。方法患者共80名,纤溶酶处理组40例,联合治疗处理组40例。采用活血化瘀方联合纤溶酶治疗及单纯纤溶酶治疗。检测D-D二聚体,炎症细胞因子肿瘤坏死因子(TNF-α)、白介素(IL)-1、IL-6、内皮素(ET-1)的变化情况,观察临床治疗效果。结果联合治疗组的D-D二聚体含量下降速度更快,明显低于单纯纤溶酶处理组,差异有统计学意义(P<0.05)。纤溶酶组和联合治疗组中4种炎症因子含量之间比较差异有统计学意义(P<0.05)。但是在2组中4种炎症因子含量都较治疗前有所下降,而联合治疗组中炎症因子含量下降更为明显。纤溶酶组和联合治疗组的临床有效率都达到了90%以上,联合治疗组可以显著提高LEDVT的治愈率(治愈率由纤溶酶组的15%提高到22.5%,P<0.05),临床显效率2组之间比较差异无统计学意义。而临床治疗无效率,联合治疗组显著低于纤溶酶组。总有效率联合治疗组也高于纤溶酶组(P<0.05)。结论活血化瘀方联合纤溶酶治疗急性LEDVT,临床效果比单纯应用纤溶酶治疗有显著改善,说明活血化瘀与西药的有机结合运用,辨病辨证相结合可以提高临床疗效。 Objective To study the effect of the combined therapy of Huoxuehuayu recipe with fibrinolysis enzyme in lower extremity deep venous thrombosis （LEDVT） patients. Methods The 80 LEDVT patients were randomized into two groups ： the combined therapy group （ huoxuehuayu recipe with fibrinolysis enzyme）（ n = 40） and fibrinolysis en- zyme therapy group （n = 40）. The concentration of D-D dimer, TNF-α, IL-1, IL-6, ET-1 were examined. The clini- cal effect was also recorded. Results The significant difference in the decrease rate of D-D dimer between the two groups indicated that the combined therapy was much better than the fibrinolysis enzyme therapy （ P 〈 0.05 ）. Although the concentration of inflammatory factors was down-regulated in two groups, but the decrease rate of the combined therapy （90%） was much faster than the fibrinolysis enzyme therapy （ P 〈 0.05 ）. Furthermore, the curing rate of combined therapy was higher than the fibrinolysis enzyme therapy （The curing rate of the combined therapy was 22.5%, but the curing rate of fibrinolysis enzyme therapy was 15% ）（P 〈 0.05 ）. Conclusion Compared with the canonical fibrinolysis enzyme therapy, combined therapy could significantly decrease the concentration of inflammatory factors, can improve the clinical effective.

作者姚佳春

机构地区武警北京总队医院中医科

出处《吉林中医药》 2015年第11期1142-1145,共4页 Jilin Journal of Chinese Medicine

基金北京市中医药科技项目(JJ2003-5)

关键词下肢深静脉血栓形成活血化瘀方炎症细胞因子中西医结合疗法 lower extremity deep venous thrombosis Huoxuehuayu recipe inflammatory factors combine traditionalChinese and Western medicine therapy

分类号 R364.1 [医药卫生—病理学]