摘要
目的：探讨桂枝茯苓胶囊联合米非司酮治疗子宫肌瘤临床治疗效果，并观察和分析其对患者生活质量的影响。方法选取子宫肌瘤患者138例，采用数字表法随机分为对照组和观察组各69例。对照组应用米非司酮治疗；观察组应用桂枝茯苓胶囊联合米非司酮治疗。观察两组治疗效果、肿瘤体积变化、检测治疗前后卵泡生成激素（FSH）、雌二醇（E2）和促黄体生成激素（LH）水平，评估生活质量及不良反应。结果观察组总有效率92．75％（64／69），高于对照组的82．61％（57／69），差异有统计学意义（χ2＝10．16， P ＜0．05）；观察组治疗后瘤体体积（13．35±1．17）cm3，小于对照组治疗后的（15．64±1．33）cm3，差异有统计学意义（t ＝9．04，P ＜0．05）。观察组治疗后 FSH 和 LH 分别为（30．55±6．14）U ／L 和（32．02±7．12）U ／L，均低于对照组治疗后的（38．27±6．75）U ／L 和（36．91±5．38）U ／L，差异均有统计学意义（t ＝9．07、7．98，均 P ＜0.05）；观察组治疗后 E2为（53．41±5．13）pmol／L，高于对照组治疗后的（47．82±5．19）pmol／L，差异有统计学意义（t ＝8．76，P ＜0．05）。观察组治疗后经期和月经量分别为（4．62±0．81）d 和（52．36±6．21）mL，均少于对照组治疗后的（6．71±0．86）d 和（60．75±6．86）d，差异均有统计学意义（t ＝8．61、9．29，均 P ＜0．05）；观察组治疗后总体生活质量、躯体功能、情绪功能和社会功能均高于对照组治疗后，差异均有统计学意义（t ＝10.26、9．69、10．13、10．27，均 P ＜0．05）。结论桂枝茯苓胶囊联合米非司酮治疗子宫肌瘤具有较好的临床疗效，能够显著改善患者性激素水平和月经状况，提高其生活质量，具有较高的安全性。
Objective To explore the clinical effect of cassia twig tuckahoe capsule combined with mifepris-tone in the treatment of myoma of uterus,and to observe and analyze its influence on the quality of life,thus to provide basis for clinical treatment of uterine fibroids.Methods 138 patients with myoma of uterus were selected randomly. They were randomly divided into the control group and the observation group,69 cases in each group.The control group received mifepristone treatment,and the observation group received cassia twig tuckahoe capsule combined with mifepristone.The treatment effect of the two groups,tumor volume change were observed,follicle generate hormone （FSH）,estradiol （E2 ）and luteinizing hormone （LH）generated levels before and after treatment were detected,the quality of life and adverse reaction were assessed.Results The total effective rate of the observation group was 92.75% （64 /69）,which was higher than the control group [82.61% （57 /69）],the difference was statistically significant （χ2 =10.16,P 〈0.05 ）.The tumors volume of the observation group after treatment was （13.35 ± 1.17）cm3 ,which was lower than the control group after treatment （15.64 ±1.33）cm3 ,the difference was statistically significant （t =9.04,P 〈0.05）.FSH and LH levels of the observation group after treatment were （30.55 ±6.14）U /L and （32.02 ±7.12）U /L,which were lower than the control group after treatment[（38.27 ±6.75）U /L and （36.91 ± 5.38）U /L],the differences were statistically significant （t =9.07,7.98,all P 〈0.05）.E2 of the observation group after treatment was （53.41 ±5.13）pmol/L,which was higher than the control group after treatment[（47.82 ± 5.19）pmol/L],the difference was statistically significant （t =8.76,P 〈0.05）.The period and menstrual volume of the observation group after treatment were （4.62 ±0.81）d and （52.36 ±6.21）mL,which were less than the control group after treatment[（6.71 ±0.86）d and （60.75 ±6.86）d],the differences were statistically significant （t =8.61,9.29,all P 〈0.05）.The overall quality of life,physical function,emotional function and social function of the observation group after treatment were higher than the control group,the differences were statistically significant （t =10.26,9.69,10.13,10.27,all P 〈0.05）.Conclusion Cassia twig tuckahoe capsule in combination with mifepris-tone in the treatment of myoma of uterus has better clinical curative effect,which can significantly improve sex hormone levels and menstrual status,and improve the quality of life.It has high security.
出处
《中国基层医药》
CAS
2015年第21期3225-3228,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
桂枝茯苓胶囊
米非司酮
子宫肌瘤
临床效果
生活质量
Cassia twig tuckahoe capsule
Mifepristone
Myoma of uterus
Clinical effect
Quality of life
