摘要
目的探讨不同抗凝方法对连续性血液净化（CBP）治疗重症脓毒血症的临床疗效。方法以我院2013年3月至2015年3月收治的65例重症脓毒血症患者为研究对象，根据不同抗凝方法将其分为低分子肝素组与无肝素组，比较两组CBP治疗前、治疗后24h凝血功能指标、血栓前体蛋白（TpP）、治疗后第28天存活率。结果两组治疗后24hPT、TT、APTT、Fg、TpP较治疗前均明显下降，差异有统计学意义（P〈0．05），但治疗后两组间比较差异无统计学意义（P〉0．05）。无肝素组治疗后第28天存活率为40．O％，与低分子肝素组的53．3％比较，差异无统计学意义（P〉0．05）。结论无肝素／低分子肝素连续性血液净化均能明显改善患者凝血功能，降低TpP水平，提高重症脓毒血症患者存活率。
Objective To explore the clinical curative effect of continuous blood purification with different anticoagulation methods （CBP） in the treatment of severe sepsis. Methods 65 patierits with severe sepsis admitted into our hospital from March, 2013 to March, 2015 were selected as study objects and were divided into a low molecular heparin （LMWH） group and a non-heparin group according to different anticoagulation methods. The coagulation indexes and thrombus precursor protein （TpP） before and 24 h after CBP and the survival rates 28 days after the treatment were compared between these two groups. Results PT, TT, APTT, Fg, and TpP were significantly lower 24 h after than before the treatment in both groups, with statistical differences （P 〈 0.05）. There were no statistical differences in PT, TT, APTT, Fg, and TpP between these two groups after the treatment （P 〉 0.05）. 28 days after the treatment, the survival rate was 40.0% in the non-heparin group and was 53.3% in the LMWH group, with no statistical difference （P 〉 0.05）. Conclusions Continuous blood purification without heparin or with low molecular heparin for patients with severe sepsis can improve the patients＇ coagulation function, lower their TpP level, and increase their survival rate.
出处
《国际医药卫生导报》
2015年第21期3186-3188,共3页
International Medicine and Health Guidance News
关键词
连续性血液净化
重症脓毒血症
抗凝
凝血功能
Continuous blood purification
Severe sepsis
Anticoagulation
Coagulation function
