摘要
由犬瘟热病毒引起的犬瘟热(Canine distemper,CD)疾病,是造成犬及部分食肉目动物的一种具有高度传染性和高死亡率的疾病。犬瘟热病毒感染犬产生抗体的规律在临床上具有非常重要的意义。幼犬在出生后约35 d就失去了母源抗体的保护,需要人工对其进行预防免疫,以获得针对该病毒的特异性抗体。犬瘟热病毒在进入机体后,引起以胸腺依赖性的B2细胞所介导的体液免疫为主,初次免疫应答产生的Ig M稍多于Ig G,再次免疫应答时记忆性B细胞发挥着主要的作用,在很短时间内使得特异性Ig G抗体达到较高水平,且在机体内维持很久的时间。通过掌握Ig M和Ig G抗体产生的量及变化规律,可以诊断疾病发生的过程,为疾病的治疗和预防提供诊断依据。
Canine distemper, caused by canine distemper virus, is a disease that causes carnivore animals highly contagious and high mortality. Puppies lost the protection of the maternal antibody after being borned in about 35 days. By that time, the artificial immune to their prevention is needed, so that they can obtain the specific antibodies against the virus. After the canine distemper virus enters the body, the humoral immunity mediated by the thymus dependent B2 cells is caused. For the first time of the immune response, IgM is produced slightly more than IgG. For the second time of the immune response, memory B cells play a major role, it makes specific IgG antibody achieve a higher level and maintain longer in a short time. The disease process can be diagnosed by grasping the amount of IgM and IgG and its change rule, which provides the diagnosis basis for the treatment and prevention of the disease.
出处
《安徽农业科学》
CAS
2015年第30期116-118,共3页
Journal of Anhui Agricultural Sciences
基金
公益性行业专项(201303040-15)
