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CysC与NT-proBNP对急性心力衰竭患者病情和预后的评估 被引量：10

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摘要 目的研究血浆半胱氨酸蛋白酶抑制剂C(cystatin C,CysC)和N末端脑钠肽前体(N-terminal probrain natriuretic peptides,NT-proBNP)对急性心力衰竭患者病情和预后的评估作用。方法选取2013年1月至2014年6月急诊心力衰竭患者115例,选取同期健康体检者58例为对照组,分别给予血浆NT-proBNP和CysC水平检查,比较观察组和对照组NT-proBNP和CysC的区别,根据临床心功能情况患者分成Ⅱ级36例,Ⅲ级39例和Ⅳ40例,分别比较NT-proBNP和CysC与心力衰竭严重程度的相关性。心力衰竭组根据预后分为事件组51例及非事件组64例,分别比较2组NT-proBNP和CysC的区别。结果心力衰竭组NT-proBNP、CysC水平均高于对照组(P=0.001)。NT-proBNP和CysC与心力衰竭严重程度呈正相关性(r=0.359,0.426,P=0.002,0.003),事件组NT-proBNP、CysC均高于非事件组(P=0.001,0.015)。结论 NT-proBNP和CysC水平能够评估急性心力衰竭患者病情和预后,NT-proBNP和CysC水平越高,病情越重,预后越差。
作者 董自平 高峰 路桂杰 王滨 刘强
机构地区 华北石油管理局总医院急诊科 华北石油管理局总医院井下医院检验科 华北石油管理局总医院重症医学科 华北石油管理局总医院采一社区服务中心
出处 《河北医药》 CAS 2015年第19期2952-2954,共3页 Hebei Medical Journal
关键词 急性心力衰竭 NT-PROBNP 半胱氨酸蛋白酶抑制剂C 预后
分类号 R541.61 [医药卫生—心血管疾病]
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参考文献21

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河北医药
2015年 第19期

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