摘要
目的研究类风湿关节炎（RA）患者血清中组织蛋白酶S（Cat S）的表达情况及与DAS-28的关系。方法选取64例RA患者，评估其疾病活动度（DAS28-ESR和DAS28-CRP），检测其外周血中CatS和Ⅱ型胶原表达的变化情况，同时收集64例健康体检者作为对照组，应用GraphPad Prism5．01软件进行统计分析。结果与对照组比较，RA患者血清中CatS显著升高[（53．68±25．71）ng／ml比（3．09±1．83）ng／ml，P〈0．01]，且与DAS28-ESR、DAS28-CRP和类风湿因子（RF）呈正相关，而与抗环瓜氨酸肽（CCP）抗体间无关。而Ⅱ型胶原的表达与DAS28-ESR、DAS28-CRP、RF和抗CCP抗体间均无相关，但CatS与Ⅱ型胶原间呈负相关（r=-0．381，P〈0．05）。结论CatS可能参与RA的发病过程，其表达变化与疾病活动度相关。
Objective To investigate the correlation of serum Cat S and disease activity score （DAS）-28 in the rheumatoid arthritis （RA） patients. Mehods 64 patients of rheumatoid arthritis were enrolled. The disease activity, DAS 28-ESR and DAS 28-CRP were evaluated. The expression of Cat S and collagen Ⅱ in serum were detected. Statistical analysis by GraphPad Prism 5.01. Results The expression Cat S of in the serum was much higher than that of the control [ （53.68 ± 25.71 ） ng/ml vs （ 3.09 ± 1.83 ） ng/ml,P 〈0.01 ]. The level of Cat S was linear correlated with the disease activity of rheumatoid arthritis and the level of rheumatoid factor, but was not correlated with the level of anti-CCP. On the contrary, the level of collagen Ⅱ was not correlated with the disease activity of rheumatoid arthritis, the level of rheuma- toid factor or the level of anti-CCP,but was negative correlated with the level of Cat S（ r = -0. 381 ,P 〈 0.05）. Conclusion Cat S should be involved in the pathogenesis of rheumatoid arthritis and the expres- sion in serum of RA patients was correlated with the disease activity.
出处
《临床内科杂志》
CAS
2015年第10期680-682,共3页
Journal of Clinical Internal Medicine
基金
国家自然科学基金面上项目（30972747、81172875）
