摘要
背景动物实验研究证实，干细胞移植可以治疗多种神经退行性疾病和缺血性脑卒中。近年研究发现，其对慢性顽固性疼痛也有很好的治疗效果。目的综述干细胞移植对各种慢性顽固性疼痛的治疗作用及其机制。内容干细胞可应用于外周神经损伤导致的神经病理性疼痛（neuropathicpain，NP）、糖尿病周围神经痛、脊髓损伤（spinalcordinjury，SCI）后慢性疼痛以及下肢缺血性疼痛的治疗，主要机制是修复和免疫调节效应。趋向干细胞有望成为未来慢性顽固性疼痛治疗的重要手段。
Background Animal experiments have demonstrated that stem cell transplantation relieves various neurodegenerative diseases and ischemic stroke. Recent studies indicate that it may also be a therapeutic approach for intractable chronic pain management. Objective To review the application and potential mechanisms of stem cell transplantation for management of intractable chronic pain. Content Stem cell transplantation can be used for treatment of the neuropathic pain（NP） induced by peripheral nerve injury and diabetic peripheral neuropathy, and chronic pain involving spinal cord injury（SCI） and limb ischemia. Furthermore, the analgesic mechanisms include the repairing and immunomodulation properties. Trend Stem cell transplantation provides a new tool for the relief of intractable chronic pain.
出处
《国际麻醉学与复苏杂志》
CAS
2015年第10期945-949,共5页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金（81171055,81428008）
北京市卫生系统高层次卫生技术（人才学科骨干）培养计划
北京市自然科学基金（7152056）
