摘要
目的研究多发性硬化(MS)患者认知功能损害的特点,了解脑萎缩对认知功能的影响。方法选择23例M S患者(M S组)和23例健康志愿者(对照组),采用神经心理学测验评估患者的整体认知及注意、执行、信息处理速度等认知功能,行颅脑磁共振成像(MRI)测量两组第三脑室宽度。结果与对照组相比,MS组整体认知功能下降(P<0.05),执行、注意及信息处理速度存在功能受损(P<0.05)。MS患者第三脑室宽度较对照组增宽[(4.96±0.77)vs(3.82±0.38)mm,P<0.05)]。数字符号模拟测验(SDMT)及色词测验(CWT)第3部分结果与病程有相关性(r=-0.430及0.455,P<0.05);SDMT结果与EDSS呈负相关(r=-0.505,P<0.05)。第三脑室宽度与词语流畅性测验(VFT)、数字广度测验(DST)及SDMT结果呈负相关(r=-0.511^-0.595,P<0.05),与连线测验(TM T-B)及CWT结果呈正相关(r=0.571及0.549,P<0.05)。结论 M S患者存在认知功能损害,以执行、注意及信息处理速度受损为主,认知障碍与脑萎缩存在相关关系。
Objective To investigate the characteristics of cognitive impairment in patients with multiple sclerosis（ MS） and explore the correlation between neuropsychological test and the third ventricle width. Methods Twentythree patients with MS（ MS group） and 23 healthy controls（ control group） were enrolled in the study. The two groups were submitted to a battery of neuropsychological tests to assess general cognitive function,executive function,attentional function and information processing speed. Each group underwent brain magnetic resonance imaging（ MRI） test.The third ventricle width was also measured. Results Compared with control group,the general cognitive function,executive function,attentional function and information processing speed of MS group obviously decreased（ P〈0. 05）.The width of the third ventricle increased in MS group,compared with control group[（ 4. 96 ± 0. 77） vs（ 3. 82 ± 0. 38）mm,P〈0. 05） ]. The results of symbol digit modalities test（ SDMT） and the third part of color word test（ CWT）were associated with disease duration（ r =- 0. 430 and 0. 455,P〈0. 05）. SDMT result showed negative relation with EDSS scores（ r =- 0. 505,P〈0. 05）. Verbal fluency test（ VFT）,digit span test（ DST） and SDMT also showed negative relations with the width of the third ventricle（ r =- 0. 511 ^- 0. 595,P〈0. 05）,while the results of trail making test（ TMT） and CWT showed positive relations with the width of the third ventricle（ r = 0. 571 and 0. 549,P〈0. 05）. Conclusion The impaired aspects of cognition in MS mainly involve executive function,attentional function and information processing speed. The width of the third ventricle has an influence on cognitive impairments in MS patients.
出处
《山东大学学报（医学版）》
CAS
北大核心
2015年第10期51-54,共4页
Journal of Shandong University:Health Sciences
基金
国家自然科学基金(81171171
81100802)
关键词
多发性硬化
认知障碍
神经心理学测评
脑萎缩
Multiple sclerosis
Cognitive impairment
Neuropsychological tests
Cerebral atrophy
