摘要
目的评价雷替曲塞联合紫杉醇二线治疗晚期胃癌的近期疗效和不良反应。方法选择一线化疗治疗失败或缓解后再进展的晚期胃癌患者80例,随机分为观察组和对照组,每组40例。观察组采用雷替曲塞联合紫杉醇方案化疗,对照组采用氟尿嘧啶联合紫杉醇方案化疗,观察2组患者临床疗效、肿瘤标记物水平、症状缓解情况及不良反应。结果观察组和对照组总有效率(ORR)分别为45.0%(18/40)和40.0%(16/40)(P>0.05);2组患者治疗后癌胚抗原(CEA)和糖类抗原(CA72-4、CA199)水平较治疗前均下降(P<0.05)。治疗后症状评分均较治疗前下降,且观察组均优于对照组(P<0.05)。观察组中性粒细胞减少、恶心呕吐、乏力及谷丙转氨酶(ALT)升高的发生率明显低于对照组(P<0.05)。结论雷替曲塞联合紫杉醇方案二线治疗晚期胃癌疗效好,不良反应轻。
Objective To evaluate the short-term clinical efficacy and adverse reactions of raltitrexed combined with paclitaxel as a second-line treatment for patients with advanced gastric cancer. Methods A total of 80 patients with failure of first-line treatment or re-progression after remission were selected and randomly divided into observation group and control group,40 cases in each group.The observation group was treated with raltitrexed combined with paclitaxel chemotherapy,while the control group was treated with 5-fluorouracil combined with paclitaxel chemotherapy. Clinical efficacy,tumor marker levels,symptom remission condition and adverse reactions were compared between two groups. Results The overall response rates（ ORR） in the observation group and the control group were 45. 0%（ 18 /40） and 40. 0%（ 16 /40） respectively（ P 0. 05）. Carcinoembryonic antigen（ CEA） and carbohydrate antigen（ CA72-4 and CA199） levels in both groups decreased markedly after treatment（ P 0. 05）. Symptom score decreased notably after treatment than treatment before,and it was obviously better in the observation group than in the control group（ P 0. 05）. The incidence of neutropenia,nausea,vomiting,fatigue and alanine aminotransferase elevation in the observation group was significantly lower than that in the control group（ P 0. 05）. Conclusion Raltitrexed combined with paclitaxel as a second-line chemotherapy for advanced gastric cancer shows a favorable clinic effect,and its adverse reactions are slight.
出处
《实用临床医药杂志》
CAS
2015年第19期19-21,25,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11522668)
关键词
晚期胃癌
雷替曲塞
紫杉醇
5-氟尿嘧啶
advanced gastric cancer
raltitrexed
paclitaxel
5-fluorouracil
