摘要
目的 :探讨内皮素在脑梗塞发病中的作用及其临床意义。方法 :运用放射免疫方法测定脑梗塞患者血浆及脑脊液中内皮素的含量 ,应用SPSS软件包进行统计学分析。结果 :患者急性期血浆、脑脊液内皮素水平均显著高于对照组。伴高血压的患者急性期血浆内皮素较不伴高血压的患者显著升高 ,而脑脊液水平虽高 ,但差异没有显著性。患者急性期血浆内皮素水平与血脂、纤维蛋白原及血液流变学均无显著相关关系。结论 :内皮素在脑梗塞发病中并非通过脂质代谢异常或血液流变学改变等因素起作用 。
Objective: To investigate the possible roles of endothelin 1 in the pathogenesis of cerebral infarction. Methods: We observed endothelin-1 concentration in plasma and CSF in patients and control group by using radioimmunoassay.All datum analyses were performed with SPSS. Results: There was a marked elevation in endothelin 1 levels in plasma and CSF in the patients groups,and endothelin 1 levels in plasma in the patients with hypertension were significantly higher than those with non hypertension. However, the endothelin 1 levels in CSF in these patients were higher than those with non hypertension without a statistical significance.there was no correlation between endothelin 1 concentration in patient groups and blood lipids?fibrinogen and hemorrheological properties. Conclusion: Endothelin 1 plays a special role in the pathogenesis of cerebral infarction.
出处
《武汉大学学报（医学版）》
CAS
2002年第3期244-245,257,共3页
Medical Journal of Wuhan University
