摘要
目的探讨血清25羟维生素D3水平与哮喘患儿病情严重程度及病情控制的相关性。方法将144例哮喘患儿按脬发病时病情程度分为轻度间歇组（n=35例）、轻度持续组（n=36例）、中度持续组（n=48例）及重度持续组（n=25例），同时选取50例健康儿童作为对照组，检测所有患儿及对照儿童血清25-（OH）D，水平；治疗4周后按照儿童哮喘控制测试（C-ACT）对患儿哮喘控制情况给予评价，将所有患儿分为未控制组、部分控制组及完全控制组，比较各组血清25-（OH）D，水平的差异。结果对照组、轻度间歇组、轻度持续组、中度持续组、重度持续组5组之间血清25-（OH）D，水平存在统计学差异（P〈0．05），从对照组到重度持续组血清25-（OH）D，水平逐渐降低（P〈0．05）；完全控制组、部分控制组及未控制组三组血清25-（OH）D，水平亦存在统计学差异（P〈0．05），从完全控制组到未控制组血清25．（OH）D，水平亦呈现逐渐降低趋势（P〈0．05）；等级资料的Spearman等级相关分析显示：血清25．（OH）D，水平与病情严重程度呈负相关（L=-0．489，P〈0．05），血清25-（OH）D，水平与C-ACT评分亦呈负相关（rs-0．470，P〈0．05）；多因素Logistic回归分析显示：随着血清25-（OH）D，水平下降程度的加重，患儿发生重度持续发作、出现C-ACT评分〈19分的风险值（OR）则逐渐增大。结论血清25-（OH）D，水平与哮喘患儿病情严重程度及病情控制情况具有某种程度的相关性，早期血清维生素D水平对于评估哮喘患儿病情及近期预后具有-定的临床意义。
Objective To investigate the correlation between serum vitamin D3 level and disease severity and disease control in children with asthmatic. Methods 144 cases of children with asthma were divided into mild intermittent group （ n = 35 cases） , mild group （n=36 cases）, moderate group （n=48 cases） and severe group （n=25 cases） according to the degree of the disease, and 50 cases of healthy children were selected as control group. Serum 25-（OH） D3 level was detected in control children and asthma children and the childhood asthma control test （C-ACT） was used for evaluation of children with asthma con- trol after 4 weeks treatment. All asthma children were divided into not controlled group, partly controlled group and completely controlled group according to the C-ACT, and serum 25-（ OH ） D3 levels were compared between groups. Results There were statistically significant differences in serum 25-（OH） D3 levels among the control group, mild intermittent group, mild group, moderate group, and severe group （P〈0.05）, and from control group to severe group serum, serum 25-（OH） D3 levels gradually decreased （P〈O. 05 ）. There were statistically significant differences in serum 25-（OH） D3 levels among not controlled group, partly controlled group and completely controlled group （ P〈0.05 ）, and from completely controlled group to not controlled group, serum 25-（OH）D3 levels gradually decreased （P〈0.05）. Spearman correlation analysis showed that serum 25-（OH）D3 level was negatively correlated with disease severity （rs =-0. 489, P〈0.05 ）, and serum 25-（OH） D3 level was also negatively correla- ted With C-ACT score （ rs = -0. 470, P〈0.05 ）. Multivariable logistic regression analysis showed that risk ratio of asthma children with severity and C-ACT score 〈19 points of value increased gradually when the serum 25-（OH） Dz level decreased. Conclusion Serum 25-（OH） D3 level is closely related to asthmatic severity and disease control, and early detection of serum vitamin D level has a certain significance in evaluation asthmatic severity and recent prognosis in children with asthma.
出处
《中国医院统计》
2015年第4期270-273,共4页
Chinese Journal of Hospital Statistics
