摘要
目的分析维持性血液透析患者血尿酸水平与循环内皮细胞的关系,探讨高尿酸在心血管疾病的发生、发展中的作用。方法选择维持性血液透析患者60例,分为血尿酸升高组(35例)和血尿酸正常组(25例),并收集其临床资料及血清标本,测定血尿酸、血脂、电解质、肝肾功能、CRP、CEC等。结果血尿酸升高组高血压的发生率高于血尿酸正常组(P<0.05)。尿酸升高组中ALB、LDL、P、BUN、Cr、CRP的水平显著高于尿酸正常组(P<0.05),而残余肾功能滤过率低于尿酸正常组(P<0.05)。单因素相关分析显示UA与ALB、LDL、P、BUN、Cr、CRP呈正相关,与GFR呈负相关。透析患者透析前CEC较健康成人明显增高,透析结束后CEC水平显著降低(P<0.05),但随着透析结束时间延长又逐渐增高,其变化趋势与血尿酸水平呈正相关(P<0.05)。结论维持性血液透析患者高尿酸可能损伤或激活血管内皮细胞,加重血管内皮损害,促进心血管疾病的发生发展。
Objective To analyze the association between blood uric acid and circulating endothelial cells in maintenance hemodialysis patients and explore the role of high uric acid in the occurrence and development of cardiovascular disease .Methods The study included 60 MHD patients who were divided into hyperuricemia group （ n=35 ） and normouricemia group （ n=25 ） .The clinical data and serum specimens were collected.Serum sample were collected for the determination of uric acid , blood lipids, blood electrolyte, liver and kidney function , CRP, CEC etc.Results The incidence of high blood pressure was higher in hyperuricemia group than normouricemia group （P〈0.05）.The levels of ALB, LDL, P, BUN, Cr and CRP in hyperuricemia group were higher than those of normouricemia group （ P〈0.05）, but the level of residual kidney filtration rate was lower than that of normouricemia group （P〈0.05）.Single factor analysis showed UA was positively correlated with ALB, LDL, P, BUN, Cr and CRP,and was negatively correlated with GFR .The level of CEC in pre -dialysis patients was significantly higher than that in healthy adults and CEC decreased significantly after the end of dialysis （P〈0.05）.The level of CEC was gradually increased with the extension of time after the end of dialysis, its trends were positively correlated with the level of serum uric acid （P〈0.05）.Conclusions High uric acid may damage or activate endothelial cells in maintenance hemodialysis patients .It may aggravate vascular endothelial damage , and promote the development of cardiovascular disease .
出处
《齐齐哈尔医学院学报》
2015年第27期4068-4070,共3页
Journal of Qiqihar Medical University
基金
福建省卫生厅课题项目(福建省青年科研课题
项目编号2012-1-34)
关键词
维持性血液透析
血尿酸
循环内皮细胞
Maintenance hemodialysis
Blood uric acid
Circulating endothelial cells
