摘要
用NT—P—BSA致敏明胶颗粒的凝集试验和NT—O—BSA为包被抗原的ELISA检测了1334份血清,发现1309例的两种试验结果一致,其中120例均为阳性。1189例均为阴性,符合率达98.1％。在职业接触者、社会接触者和肺结核患者中两种试验均阳性的分别为1.7％、2.16％和0％,与正常人群的2％无明显差异。家庭内接触者的阳性率高达8.04％,是正常人的4倍,对这些阳性者正在随访。因NT—P—BSA致敏明胶颗粒的凝集试验阳性主要见于查菌阳性的BL—LL患者,而正常人群和肺结核患者的阳性率极低,提示这一试验检测抗PGI抗体的持异性很高,似可用于发现高危人群和早期传染性病例。
Agglutination tests with gelatin particles sensitized by NT—P—BSA and ELISA with NT—O—BSA as coating antigen were made in 1334 specimens of serum. The results showed the coincidence of the both in 1309 specimens, including 120 positive and 1189 negative in both the tests, with a coincidence rate of 98.1％. The positive rate in both tests at the same time is 1.7％ in vocational contacts with leprosy, 2.16％ in social contacts and 2％ in healthy population. The patients with tuberculosis all showed negative in the both. There was no significant difference among them. But the positivity in the household contacts with leprosy was 8％, being four times that in the healthy population. The positive household contacts are being followed. The positivity in the GPAT was mostly seen in BL—LL leprosy patients, indicating that the GPAT has higher specificity to the antibody against PG1 and seems to be useful in the detection of early cases of leprosy and the population at risk of confracting leprosy.
