摘要
目的探究酪酸梭菌肠球菌三联活菌片联合灌肠疗法治疗小儿腹泻的临床疗效及对血清白细胞介素(IL-6)、肿瘤坏死因子(TNF-α)等炎性因子的影响。方法选取2012年4月至2014年4月间收治的156例小儿腹泻患者作为研究对象。将其随机分为三组,每组52例。观察组采用酪酸梭菌肠球菌三联活菌片联合灌肠疗法进行治疗,蒙脱石组采用蒙脱石联合灌肠疗法治疗,对照组采用常规治疗。观察三组患者临床体征消退的时间、治疗有效率及炎性因子IL-6、TNF-α水平。结果治疗有效率上,观察组和蒙脱石组总有效率分别达98.08%和96.15%,明显高于对照组的总有效率78.85%(41/52),差异具有统计学意义(P<0.05)。在相关临床症状上,与对照组相比,观察组和蒙脱石组退热、呕吐缓解、腹痛缓解、便检正常及住院时间均显著缩短(P均<0.05),而两治疗组之间比较差异无统计学意义(P均>0.05)。治疗后,与对照组相比,观察组与蒙脱石组炎性因子IL-6和TNF-α水平均明显下降(P均<0.05),而观察组与蒙脱石组比较差异无统计学意义(P均>0.05)。同时,蒙脱石组出现1例便秘患儿,经减量后恢复正常。结论酪酸梭菌肠球菌三联活菌片联合灌肠能够有效治疗小儿腹泻,治疗效果与蒙脱石保留灌肠相似,可缩短患儿的住院时间,减轻炎性反应,值得在临床上进行合理利用。
Objective To explore the clinical effect of Clostridium butyricum TO- A combined with enema therapy in treatment of pediatric patients with diarrhea,and to observe its influence on serum IL- 6,TNF etc inflammatory factors. Methods One hundred and fifty six patients with infantile diarrhea admitted in this hospitalduring April 2012 to April 2014 were allocated in this study,they were randomly divided into three groups,and 52 patients in each group. Patients in observation group were administrated with Clostridium butyricum TO- A combined with enema,and patients in montmorillonite group were treated by montmorillonite combined with enema,andpatients in control group were applied with conventional treatment. Then,the duration for regression of clinical symptoms,treatment efficiency and changes in inflammatory factors of IL- 6and TNF- α were observed and compared. Results The total effective rate of patients in observation group was 98. 08%,that of patients in montmorillonite group was 96. 15%,that of patients in control group was 78. 85%,and the difference was statistically significant（ P〈0. 05）. In the remittence of clinical symptoms,in comparison with control group,the duration fordisappearance of fever,vomiting,abdominal pain,duration for normalization of stool analysis and hospitalization inpatients of observation group and montmorillonite group were shorter than those of patients in control group,the difference was statistically significant（ all P〈0. 05）,while there＇s no statistical difference between patients inobservation group and montmorillonite group（ all P〈0. 05）. As to inflammatory factors,in comparison with control group after treatment,levels of IL- 6 and TNF- α were statistically lowered in those of observation group andmontmorillonite group（ all P〈0. 05）,while there was no statistical difference between observation group andmontmorillonite group（ both P〉0. 05）. At the same time,constipation occurred in one case of montmorillonite group at2 days after treatment,and he had returned to normal after decrease of the dosage. Conclusion The efficacy of Clostridium butyricum TO- A combined with enema is similar to that of montmorillonite retention enema in treatment of patients with infantile diarrhea,it can shorten the duration for hospitalization and alleviate inflammatory reactions without severe adverse reactions,hence it is worthy to be rationally applied for clinical administration.
出处
《临床和实验医学杂志》
2015年第20期1711-1713,共3页
Journal of Clinical and Experimental Medicine
