摘要
目的:比较吗丁啉和小剂量红霉素治疗极低出生体重儿喂养不耐受的临床疗效。方法:回顾性分析我科2011年1月至2013年12月期间收治的90例极低出生体重儿喂养不耐受患儿的临床资料。根据选用的治疗药物,将患儿分为A组(吗丁啉组,n=42)和B组(小剂量红霉素组,n=48)两组。患儿在综合治疗的基础上配合上述的药物治疗喂养不耐受的症状。观察并比较两组患儿喂养不耐受症状的消退时间、恢复出生体重时间、完全胃肠内喂养时间、住院时间及治疗副作用的发生情况。结果:两组患儿经积极干预治疗后,喂养不耐受症状消失、恢复出生体重、完全胃肠内营养等出院标准。两组患儿间上述指标实现时间及住院时间的比较未见统计学差异(P>0.05);A组患儿治疗期间未见与服用吗丁啉相关的不良反应;B组患儿有6例因静滴红霉素引起的局部疼痛发生,发生率为12.5%,未见静脉炎等不良反应发生。两组患儿间治疗副作用发生率的比较,差异具有统计学意义(P<0.05)。结论:吗丁啉和静滴低剂量红霉素均可有效治疗极低出生体重儿的喂养不耐受症状。二者的治疗效果相当,但吗丁啉可能具有更高的安全性。
Objective： To compare the efficacy of domperidone and low-dose Erythromycin in the treatment of feeding intolerance in very low birth weight infant（VLBWI）. Methods： A retrospective analysis was performed on 90 cases of VLBWI with feeding intolerance who admitted in our hospital from January 2011 to December 2013. According to the choice of therapy, the patients were divided into group A（domperidone group, n=42） and group B（low-dose erythromycin group, n=48）. On the basis of comprehensive treatment the children of different groups were treated with different drugs as mentioned above the feeding intolerance symptoms.then the subside time of feeding intolerance symptoms, time to regain birth weight, the incidence of total parenteral feeding time, duration of hospitalization and incidence of side effects were observe and compared between two groups. Results： After treatment,all the children in both groups,achieved feeding intolerance symptoms, regained birth weight, total parenteral nutrition in the discharge standards. No statistically significant difference was found in the time of indicators mentioned above between two groups（P〉0.05）. No related adverse reactions was adversed in group A,while six cases of local pain caused by intravenous erythromycin was adversed in group B,the incidence rate was 12.5%,it was significantly higher than that of group A（P 〈0.05）. Conclusion： Both domperidone and low-dose intravenous erythromycin could be effective and equal in the treatment of feeding intolerance in VLBWI. But domperidone might have higher security.
出处
《现代生物医学进展》
CAS
2015年第25期4953-4955,4996,共4页
Progress in Modern Biomedicine
基金
广东省人口计生委项目(20133097)
关键词
吗丁啉
红霉素
极低出生体重儿
喂养不耐受
Domperidone
Erythromycin
Very low birth weight infant
Feeding intolerance
