摘要
近年鉴定到Metacaspase、组织蛋白酶B、组织蛋白酶D、核酸酶(Endo G、Tatd、Fen-1)等分子参与了原虫的凋亡,但不清楚这些分子在凋亡信号途径中的位置及相互关系。实验结果显示,Metacaspase可能具有调节原虫凋亡与细胞周期等功能,但是Metacaspase与Caspase的活化方式及作用底物不同,提示原虫存在与多细胞动物不同的凋亡途径;在疟原虫及利什曼原虫中发现其线粒体及溶酶体参与了其凋亡,提示原虫可能具有类似哺乳动物的溶酶体-线粒体凋亡途径;在利什曼原虫和锥虫中发现存在通过核酸酶而不依赖Caspase的凋亡途径。阐明原虫的凋亡机制有助于通过设计新药物诱导原虫凋亡来达到治疗疾病的目的。
Recently, a number of molecules which are involved in the apoptosis in protozoa have been discovered, for ex-ample：metacaspase, cathepsin B and D, nuclease（ Endo G, Tatd, Fen-1 et al） .So far the locations of these molecules in the signal pathway of protozoan apoptosis and the relationship associated to these molecules in the signal pathway have not been identified.The results of experiments showed that the activation mode is different between metacaspase and caspase. The substrates are also different for metacaspase and caspase.The results suggested that the apoptosis mechanism is different between protozoan and metazoan.Metacaspase has multifunction, for example： control of apoptosis, cell cycle and clear-ance of insoluble protein aggregates.The results of experiment showed that mitochondrial and lysosomal body are involved in the apoptosis in protozoan, possibly, there are mitochondrial-lysosomal body pathway and caspase-independent pathway which control the apoptosis in protozoan.Uncovering clearly the mechanism of apoptosis in protozoan is benefit for design of new drugs in prevention and treatment of diseases caused by the protozoa.
出处
《微生物学免疫学进展》
2015年第6期61-64,共4页
Progress In Microbiology and Immunology
