摘要
脓毒症是由病原微生物感染所致的全身炎性反应综合征。因其高发病率、高病死率及高医疗费用已引起全球关注，脓毒症成为儿科重症医学的临床研究热点。大量研究表明严重脓毒症多器官功能障碍综合征的发生与线粒体呼吸链功能障碍密切相关。组织器官氧化磷酸化功能障碍是脓毒症器官功能障碍的重要特征之一。该文就脓毒症线粒体呼吸链功能障碍的研究进展作一综述。
Sepsis is a complicated pathophysiological disorder arising from a systemic inflammatory re- sponse to infection. Because of high morbidity ,high mortality and high cost of treatment, sepsis has caused global attention and become a hot spot in pediatric intensive medical research. Increasing number of studies have shown a close correlation between the occurrence of multiple organ dysfunction syndrome and mitochondrial dysfunction in sepsis. A major feature in sepsis is dysfunction of mitochondrial oxidative phosphorylation. This review discus- ses the dysfunction of mitochondrial respiratory chain in sepsis.
出处
《国际儿科学杂志》
2015年第5期534-537,共4页
International Journal of Pediatrics
基金
北京市医院管理局临床医学发展专项,“扬帆”计划（XM201412）
关键词
脓毒症
线粒体呼吸链
Sepsis
Mitochondrial respiratory chain
