摘要
急性肾损伤是重症监护室常见的严重并发症之一，由于缺少早期诊断生物标志物，重症患儿的病死率高达印％。中性粒细胞明胶酶相关载脂蛋白是目前认为最有临床应用前景的早期诊断和预测急性肾损伤的生物指标，正常生理状态下低水平表达，病理状态下表达急速上升，患者尿液和血清出现大量蓄积。该文对中性粒细胞明胶酶相关载脂蛋白作为早期生物标志物在不同临床背景下的儿童急性肾损伤的研究作一综述。
Acute kidney injury （AKI） is the most common and serious complication in the intensive care unit. The mortality of AKI is still as high as 60% in critically ill children because of lack sensitive and special early predictive biomarker. Neulrophil gelatinase-associated lipocalin is one of the most promising early diagnose and predict biomarkers for AKI,produced and secreted by kidney tubule cells at low levels,but increasing dramatically in the urine and serum after ischemic, sepsis, or nephrotoxic injury of the kidneys. This review is to summarize the role of neutrophil gelatinase-associated lipocalin as an early biomarker of AKI with different clini- cal settings in children.
出处
《国际儿科学杂志》
2015年第5期495-498,共4页
International Journal of Pediatrics
基金
山东省医药卫生科技发展计划（2014WS0208）
山东省科技发展计划项目（2012G0021855）
山东省优秀中青年科学家科研奖励基金项目（BS2012YY001）
