摘要
目的 观察继往单用预混胰岛素治疗血糖控制不佳的肥胖2型糖尿病患者加用格列美脲的临床疗效。方法将本院2013年9月~2014年9月60例单用预混胰岛素治疗〉3个月、血糖控制不佳的肥胖2型糖尿病患者随机分为治疗组（A组）和对照组（B组）,每组30例,A组患者在调整预混胰岛素剂量的同时,予午餐前口服格列美脲,B组患者维持原治疗方案,继续调整胰岛素剂量,治疗观察3个月,比较治疗前后血糖水平、体质指数（BMI）、胰岛素剂量的变化及低血糖发生情况。结果 治疗后两组患者FPG、2 hPG、糖化血红蛋白（HbA1c）较治疗前均显著下降（P〈0.05）,但A组下降更明显（P〈0.05）,A组BMI及胰岛素剂量较治疗前显著下降（P〈0.05）,低血糖发生率为6.7%。B组患者的BMI、胰岛素剂量较治疗前显著增加（P〈0.05）,低血糖发生率为16.7%。结论 对单用预混胰岛素控制不佳的肥胖2型糖尿病患者,加用格列美脲治疗能有效降低整体血糖水平,可显著减少胰岛素用量,且对患者的体重质量有更大的获益。
Objective To observe the clinical effect of glimepiride added to single treated type 2 diabetes patients with poor glycemic control by pre mixed insulin therapy. Methods Sixty ineffective controlled obese type 2 diabetes patients in our hospital from September 2013 to September 2014 were single treated by pre mixed insulin more than 3 months were randomly divided into two groups,treatment group（group A）received aspart 30 combined with glimepiride and con- trol group（group B）continue to adjust the dose of insulin.Mter treated for 3 months,blood glucose level,body mess index （BMI）,insulin dose and incidence of hypoglycemia were compared. Results The fasting blood glucose,postprandial two hours blood glucose and HbAlc between two groups was obviously decreased respectively compared with their pre- treatment （P〈0.05）.Group A decreased more significantly （P〈0.05）.There was significant difference in BMI and insulin dose before and after treatment in group A（P〈0.05）.The incidence of hypoglycemia was 6.7%.On the contrary,there were significant increase in BMI and insulin dose after treated in group B （P〈0.O5）.The incidence of hypoglycemia was 16.7%. Conclusion For ineffective controlled obese type 2 diabetes patients were single treated by pre mixed insulin, plus glimepiride can effectively reduce blood glucose with lower incidence of hypoglycemia and the dose of insulin, maximum effect on BMI.
出处
《中国当代医药》
2015年第27期91-93,共3页
China Modern Medicine
基金
江西省赣州市指导性科技计划(GZ2014ZSF094)
关键词
格列美脲
预混胰岛素
肥胖
2型糖尿病
Glimepiride
Premixed insulin
Obese
Type 2 diabetes mellitus
