摘要
目的 探讨孟鲁司特钠联合布地奈德治疗小儿咳嗽变异型哮喘（CVA）的临床效果。方法 选择龙门县人民医院2011年8月~2013年9月收治的136例CVA患儿,随机分为观察组（n=68）与对照组（n=68）,两组患者均给予布地奈德气雾剂吸入治疗,观察组另加用孟鲁司特钠口服治疗,比较两组患儿的治疗效果。结果 治疗后两组患儿症状评分均较治疗前降低（P〈0.01）;FEV1、FEV1%及PEF较治疗前升高（P〈0.01）;治疗后观察组症状评分低于对照组（P〈0.01）,FEV1%及PEF高于对照组（P〈0.01）;观察组咳嗽、呼吸困难及哮鸣音等症状消失时间及总住院时间均短于对照组（P〈0.01）。观察组临床有效率为94.1%,对照组临床有效率为77.9%,观察组临床有效率高于对照组（P〈0.05）。结论 孟鲁司特钠联合布地奈德能改善咳嗽变异型哮喘小儿肺功能,具有较好的临床疗效。
Objective To investigate the clinical effect of montelukast sodium combined with budesonide in the treatment of children with cough variant asthma （CVA）. Methods 136 children with CVA treated in Longmen people＇s hospital from August 2011 to September 2013 were selected and randomly divided into observation group （n=68） and control group （n=68）.Both groups of patients were given budesonide aerosol treatment and the observation group was given additional oral administration of montelukast sodium.The treatment effects between two groups were compared. Results After treatment,the symptom scores between two groups was reduced compared to that before treatment respectively （P〈 0.01）,and FEV1,FEV1% and PEF increased compared to that before treatment respectively （P〈0.01）.After treatment,the symptom score of observation group was lower than that of control group （P〈0.01）,and FEV1,FEV1% and PEF of observation group was higher than that of control group respectively （P〈0.01）.The disappearance time of symptoms and signs, such as cough,dyspnea and wheeze,and the total length of hospital stay of observation group was shorter than that of control group respectively （P〈0.01）.The clinical effective rate of observation group was 94.1% and that of control group was 77.9%,with the observation group higher than the control group（P〈0.05）. Conclusion Montelukast sodium combined with budesonide can improve the lung function of children with cough variant asthma and has good clinical efficacy.
出处
《中国当代医药》
2015年第27期61-63,共3页
China Modern Medicine
