摘要
目的探讨克拉霉素联合噻托溴胺治疗慢性阻塞性肺疾病（COPD）的效果。方法选择2013年5月~2015年1月在我院治疗的72例COPD患者,按照随机数表法将其分为对照组和观察组,每组36例。对照组单纯实施噻托溴胺救治,观察组增加克拉霉素用药,均治疗4周后研究两组的临床改善情况。结果观察组的临床总有效率为94.44%,显著高于对照组的75.00%,差异有统计学意义（P〈0.05）。治疗前,两组的FEV1、FVC等肺功能指标差异无统计学意义（P〉0.05）;治疗后,两组各项肺功能指标均有所改善,且观察组的各项指标显著高于对照组,差异有统计学意义（P〈0.05）。结论对COPD患者实施克拉霉素联合噻托溴胺的救治方案,疗效安全可行,且可有效促进肺功能恢复,值得临床推广。
Objective To explore the effect of clarithromycin combined with tiotropium in the treatment of chronic ob- structive pulmonary disease （COPD）. Methods 72 patients with COPD in our hospital from May 2013 to January 2015 were selected and divided into control group and observation group according to the random indicator method,36 cases in each group.The control group was treated with only tiotropium, the observation group was treated with tiotropium combined with elarithromycin.After treating for 4 weeks,the clinical improvement in two groups was researched. Results The total effective rate in the observation group was 94.44%,which was significantly higher than 75.00%of control group,the difference was significant （P〈0.05）.Before treatment,the lung function indicators including FEVt and PVC in two groups had no statistical significance （P〉0.05）.After treatment,the pulmonary function indexes in two groups was improved,the pulmonary function indexes in observation group was significantly higher than that the control group, the difference was significant （P〈O.05）. Conclusion Clarithromycin combined with tiotropium in the treatment of patients with COPD is effective and safe,and can effective oromote the recovery of lung function,which is worthy of promotion.
出处
《中国当代医药》
2015年第26期32-33,36,共3页
China Modern Medicine
关键词
克拉霉素
噻托溴胺
慢性阻塞性肺疾病
肺功能
Clarithromycin
Tiotropium
Chronic obstructive pulmonary disease
Lung function
