急性心肌梗死CD_(34)与心功能及冠状动脉狭窄相关性研究被引量：2

Correlation Analysis of CD_(34) cells With Heart Function,Coronary Stenosis in Acute Myocardial Infarction Patients

导出

摘要目的探讨急性心肌梗死患者外周血CD34与心功能及冠状动脉狭窄的相关性和临床意义。方法选择2011年5月至2012年10月在内蒙古自治区人民医院心内科住院治疗的急性心肌梗死患者76例,根据Killip心功能分级分为KillipⅠ级组（29例）和KillipⅡ-Ⅳ级组（47例）,同期选择30例正常体检者作为对照组。采用流式细胞仪检测3组受试者外周血CD34细胞数量,入院2周内急性心肌梗死患者行心脏彩色多普勒超声检查,测定左心室射血分数（LVEF）,行冠状动脉造影,Gensini积分法计算冠状动脉狭窄程度。结果 KillipⅠ级组和KillipⅡ-Ⅳ级组CD34细胞数分别为（681±267）个/μL、（919±310）个/μL,均高于对照组的（214±23）个/μL,差异有统计学意义（P〈0.05）,且KillipⅡ组CD34细胞数高于KillipⅠ级组（P〈0.05）。KillipⅡ-Ⅳ级组Gensini积分显著高于KillipⅠ级组[（48±21）分比（30±12）分],差异有统计学意义（P〈0.01）。CD34细胞数与LVEF呈负相关（r=-0.468,P=0.000）,与Gensini积分呈正相关（r=0.301,P=0.008）。结论检测CD34细胞数量可判断急性心肌梗死患者的心功能和冠状动脉狭窄的程度,为临床判断预后提供依据。 Objective To investigate the clinical significance and correlation between peripheral blood CD34 cell number and coronary stenosis of patients with acute myocardial infarction（ AMI）. Methods A total of 76 AMI patients of the Department of Cardiology of Inner Mongolia People＇s Hospital from May 2011 to Oct. 2012,were included in the study,and another 30 people for health examination during the same period were also included as control group. The 76 patients were divided into KillipⅠ group（ 29 cases） and KillipⅡ-Ⅳ group（ 47 cases） according to Killip heart function. The general information and history of diseases and electrocardiogram were collected. CD34 cell count in peripheral blood was determined by flow cytometry,cardiac color Doppler ultrasonography were completed within two weeks to determine left ventricular ejection fraction（ LVEF）. Coronary angiography was done. Gensini integration was used to calculate the degree of coronary stenosis. Results The number of CD34 cells of KillipⅠ group and KillipⅡ-Ⅳ group were（ 681 ±267） count / μL and（ 919 ± 310） count / μL,which were higher than the control group＇s（ 214 ± 23） count / μL with statistically significant difference（ P 〈0. 05）,and the number of CD34 cells of Killip Ⅱ-Ⅳ group was higher than KillipⅠ group with statistically significant difference（ P 〈0. 05）. Gensini integral of Killip Ⅱgroup was significantly higher than KillipⅠ group [（ 48 ± 21） scores vs（ 30 ± 12） scores],the difference was statistically significant（ P 〈0. 01）. The number of CD34 cells was negatively correlated with LVEF（ r =- 0. 468,P = 0. 000）,was positively correlated with Gensini integral（ r = 0. 301,P = 0. 008）. Conclusion The number of peripheral blood CD34 cell can be used to assess the cardiac function and coronary artery stenosis degree of AMI patients,provding reference for the prognosis judgment.

作者王玲李武武安劲松

机构地区内蒙古自治区人民医院心内科

出处《医学综述》 2015年第18期3386-3389,共4页 Medical Recapitulate

基金内蒙古自治区科技计划(20110501)

关键词急性心肌梗死 CD34细胞心功能左心室射血分数 Acute myocardial infarction CD34cell Heart function Left ventricular ejection fractions

分类号 R541.1 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献23

1Wojakowski W,Kucia M,Liu R,et al.Circulating very small embryonic-like stem cells in cardiovascular disease[J].J Cardiovasc Transl Res,2011,4(2):138-144.
2Nayan M,Paul A,Chen G,et al.Superior therapeutic potential of young bone marrow mesenchymal stem cells by direct intramyocardial delivery in aged recipients with acute myocardial infarction:in vitro and in vivo investigation[J].J Tissue Eng,2011,2011:741213.
3Velagaleti RS,Pencina MJ,Murabito JM,et al.Long-term trends in the incidence of heart failure after myocardial infarction[J].Circulation,2008,118(20):2057-2062.
4Wu J,Li J,Zhang N,et al.Stem cell-based therapies in ischemic heart diseases:a focus on aspects of microcirculation and inflammation)[J].Basic Res Cardiol,2011,106(3):317-324.
5Grgaard HK,Solheim S,Landsverk KS,et al.Circulating CD34progenitor cells and growth factors in patients treated with PCI for acute myocardial infarction or stable angina pectoris[J].Scand J Clin Lab Invest,2011,71(4):322-329.
6Gkdemir MT,Kaya H.The role of oxidative stress and inflammation in the early evaluation of acute non-ST-elevation myocardial infarction:an observational study[J].Anadolu Kardiyol Derg,2013,13(2):131-136.
7Rashidinejad H,Hosseini SM,Moazenzadeh M,et al.Relationship between serum level of high-sensitive C-reactive protein and extension of myocardial involvement in patients with acute myocardial infarction[J].Rom J Intern Med,2012,50(3):211-215.
8Zuba-Surma EK,Kucia M,Dawn B,et al.Bone marrow-derived pluripotent very small embryonic-like stem cells(VSELs)are mobilized after acute myocardial infarction[J].J Mol Cell Cardiol,2008,44(5):865-873.
9Domínguez-Franco A,González FJ,Rodríguez-Losada N,et al.Factors influencing mobilisation of endothelial progenitor cells and angiogenic cytokines after an extensive acute myocardial infarction[J].Med Clin(Barc),2012,138(10):415-421.
10Strauer BE,Brehm M,Zeus T,et al.Repair of infracted myocardium by autologous intraboronary mononuclear bone marrow cell transplantation in humans[J].Circulation,2002,106(15):1913-1918.

二级参考文献24

1赵洪云,管慧红,钟雪云,陈运贤.开胸冠状动脉结扎法制作大鼠心肌梗死模型[J].国外医学（内科学分册）,2005,32(12):540-542. 被引量：18
2刘煜昊,房佰俊,史明霞,杨少光,廖联明,赵春华.人骨髓间充质干细胞在体内外分化为心血管组织[J].基础医学与临床,2007,27(6):643-647. 被引量：6
3Wollert KC,Meyer GP,Lotz J,et al.Intracoronary autologous bone-marrow cell transfer after myocardial infarction:the BOOST randomised controlled clinical trial[J].Lancet,2004,3649(9429):141-148.
4Ince H,Petzsch M,Kleine HD,et al.Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction:final 1-year results of the front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by granulocyte colony-stimulating factor (FIRSTLINE-AMI) trial[J].Circulation,2005,112(9 Suppl):173-180.
5Lane TA,Law P,Maruyama M,et al.Harvesting and enrichment of HPC mobilized into the peripheral blood of normal donors by GM-CSF or G-CSF:Potential role in allogeneic transplantation[J].Blood,1995,85(1):275-282.
6Armitage JO.Emerging applications of recombinant human granulocyte-macrophage colony stimulating factor[J].Blood,1998,92(12):4491-4508.
7Suleiman M,Khatib R,Agmon Y,et al.Early inflammation and risk of long-term development of heart failure and mortality in survivors of acute myocardial infarction predictive role of C-reactive protein[J].J Am Coll Cardiol,2006,47(5):962-968.
8Brunetti ND,Troccoli R,Correale M,et al.C-reactive protein in patients with acute coronary syndrome:Correlation with diagnosis,myocardial damage,ejection fraction and angiographic findings[J].Int J Cardiol,2006,109(2):248-256.
9Seiler C,Tilmann P,Kerstin W,et al.Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease A randomized,double-blind,placebo-controlled study[J].Circulation,2001,104(17):2012-2017.
10Wang YZH,Kristina T,Rasmus SR,et al.Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms,left ventricular perfusion and function in patients with severe chronic ischemic heart disease[J].Int J Cardiol,2005,100(3):477-483.