摘要
目的观察西洛他唑对血管性痴呆患者认知能力和血流速度的影响。方法 98例血管性痴呆患者随机分为对照组和观察组各49例,对照组应用阿司匹林治疗,观察组应用西洛他唑治疗。应用蒙特利尔认知评估量表(MoCA)评价患者认知功能,应用彩色多普勒超声显像仪探测患者大脑中动脉(middle cerebral artery,MCA),基底动脉(Basilar artery,BA)等血流速度。结果两组治疗后Mo CA总分及各子项均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组治疗后语言、视空间与执行能力、命名、注意力、抽象、记忆、延迟回忆和定向力均高于对照组治疗后,差异均有统计学意义(P<0.05);观察组治疗后MCA和BA均高于对照组,差异有统计学意义(P<0.05)。结论西洛他唑对血管性痴呆患者认知能力有显著的提高,并可改善血流速度。
Objective To effect of cognitive ability on cilostazol for the patients with vascular dementia,and to observe the influence of blood flow velocity.Method 98 patients with vascular dementia were randomly divided into a control group （ n=49） and an experimental group （ n=49） .The control group were treated with aspirin while the experimental group were treated with cilostazol.The Montreal cognitive assessment scale （ MoCA） was utilized to assess the cognitive competence of the patients.Color Doppler ultrasonography was used too detect the blood flow velocity of the middle cerebral artery （ MCA） and basilar artery （BA）.Findings The MoCA and it’s sub-item scores of both groups after treatment were higher than those before treatment.The difference was statistically significant （P〈0.05）.The total MoCA score of the experimental group after treatment was 25.01 ＋2.64, higher than that of the control group after treatment 20.76 ＋2.13.The difference was statistically significant （ P 〈0.05 ） .Language, visual spatial and executive ability, naming, attention, abstraction, memory, delayed recall and orientation of the experimental group after treatment were higher than those of the control group.The difference was statistically significant （P〈0.05）.The MCA and BA of the experimental group after treatment was higher than those of the control group.The difference was statistically significant （P〈0.05）.Conclusion Cilostazol can significantly increase the cognitive ability and ameliorate the blood flow velocity of patients with vascular dementia.
出处
《健康研究》
CAS
2015年第4期400-402,共3页
Health Research
关键词
西洛他唑
血管性痴呆
认知能力
血流速度
Cilostazol
vascular dementia
cognitive competence
blood flow velocity
