摘要
目的原发性高血压是常见的心血管疾病之一,但其发病机制尚未完全阐明。高血压是心脑血管疾病的独立危险因素,对高血压的有效管理可以降低心、脑血管事件的发生率。尽管目前可供选择的降压药物有多种,仍有部分难治性高血压患者当使用≥3种不同机制的足量降压药物,且其中至少有一种为利尿剂,血压控制仍不达标。研究表明焦虑、抑郁可能是此类患者血压难以控制的关键因素。在降压治疗基础上联合抗焦虑、抗抑郁治疗,可达到事半功倍的效果[1]。近年来,焦虑、抑郁与高血压的关系已引起广泛关注,高血压可诱发焦虑、抑郁,而焦虑抑郁也会促发并加重高血压,使原有的降压药物疗效欠佳,形成难治性高血压。本文主要对高血压伴焦虑和抑郁的研究进展做一综述,为临床诊治提供参考。
Primary Hypertension is one of common cardiovascular diseases, but its pathogenesis has not been fully clarified. Hypertension is the independent risk factors for cardiovascular and cerebrovascular diseases. The effective management of hypertension can reduce the incidence of cardiovascular and cerebrovascular events. Although there are many kinds of drugs for treating hypertension at present, still some resistant hypertension patients＇blood pressure are not up to the standard when they use greater than or equal to three different mechanisms of plenty of antihypertensive drugs, including a diuretic at least. Studies suggest that anxiety and depression may be the key factor for these patients＇uncontrolled blood pressure. Combining with anti-anxiety and depression treatment on the basis of antihypertensive therapy can get twice the result with half the effort for controlling blood pressure. In recent years, the relationship between anxiety depression and hypertension has caused wide public concern. Hypertension can bring on the occurrence of anxiety and depression. In turn, anxiety and depression can also trigger and aggravate hypertension, which makes the original anti-hypertensive drugs＇efficacy poor, developing to resistant hypertension in the end. This article mainly summarizes the research progress of hypertension combined with anxiety depression, providing a reference for clinical diagnosis and therapy.
出处
《中国分子心脏病学杂志》
CAS
2015年第4期1424-1427,共4页
Molecular Cardiology of China
基金
2010年国家临床重点专科建设项目<卫生部重点实验室项目>
"重大新药创制"科技重大专项<心血管创新药物临床研究技术平台建设>(2012ZX09303-008-001)
关键词
高血压
焦虑
抑郁
Hypertension
Anxiety
Depression
