摘要
目的:通过观察少腹逐瘀颗粒辅助治疗寒凝血瘀型原发性痛经临床疗效,从而可为临床寒凝血瘀型原发性痛经患者规范化治疗提供参考价值。方法:将2013年5月—2014年8月264例寒凝血瘀型原发性痛经者按照随机数字表法分组为对照组与观察组,各132例。对照组采用布洛芬缓释胶囊治疗;观察组加用少腹逐瘀颗粒治疗。比较两组治疗前、后疼痛变化、经血PGF2α、PGE2含量及子宫动脉血流参数变化情况、临床疗效、不良反应。结果:两组患者治疗后疼痛评分、经血PGF2α、PGE2含量及子宫动脉血流参数较治疗前明显改善,但观察组改善更显著,P<0.05;观察组治疗总有效者123例,总有效率为93.2%明显高于对照组105例,占79.5%,P<0.05;两组未见明显不良反应。结论:相比布洛芬缓释胶囊治疗来说,应用少腹逐瘀颗粒联合治疗临床疗效更显著,且安全。
Objective：To observe the clinical efficacy of adjuvant therapy Shaofu Zhuyu Particles on cold and blood stasis type of primary dysmenorrhea to provide valuable reference for clinical treatment of patients with primary dysmenorrhea. Methods ： Dur- ing May 2013 - August 2014,264 cases of primary dysmenorrhea of cold and blood stasis type of were randomly grouped into the control group and the observation group, 132 cases in each. The control group used ibuprofen therapy and observation group was treated with Shaofu Zhuyu Particles. We compared pain changes, blood PGF2α, PGE2 content and uterine artery blood flow param- eters, clinical efficacy and adverse reactions before and after treatment. Results ： Both groups pain scores, blood PGF2α, PGE2 con- tent and uterine artery blood flow parameters were improved than those before treatment, but the observation group＇s improved more significantly ,P 〈 0.05. 123 Cases were effective in treatment group and the total effective rate was 93.2 %, significantly higher than 105 cases, accounting for 79.5 % in the control group, P 〈 0.05. The two groups had no significant adverse reactions. Conclusion ： Compared to ibuprofen treatment, the applicat＇on of Shaofu Zhuyu Particles has more significant clinical efficacy and safety.
出处
《辽宁中医杂志》
CAS
北大核心
2015年第9期1703-1704,共2页
Liaoning Journal of Traditional Chinese Medicine
关键词
少腹逐瘀颗粒
寒凝血瘀型
原发性痛经
布洛芬
Shaofu Zhuyu Particles
cold and blood stasis type
primary dysmenorrhea
ibuprofen
