摘要
目的:探讨神经生长因子治疗关键部位梗死性痴呆疗效。方法:选择68例关键部位梗死性痴呆患者随机分为观察组和对照组。对照组给予常规治疗,实验组在常规治疗的基础上每日加用18μg神经生长因子注射液。以临床痴呆程度量表(CDR)、简易智能状态量表(MMSE)等评分作为疗效评价标准,比较2组患者在治疗前和治疗后(治疗4周)的认知能力、生活质量、日常生活能力的改善情况。结果:观察组患者CDR、MMSE评分优于对照组,临床症状显著改善,差异有显著性意义(P<0.05)。结论:神经生长因子可明显改善关键部位梗死性痴呆患者的临床病症以及精神状况,在一定程度上提高患者的认知功能、改善患者生活质量,对于患者的预后具有重要意义。
Objective： To discuss the influence and curative effect of nerve growth factor on strategic infarct dementi.Methods： Choose 68 cases of strategic infarction dementia patients were randomly divided into observation group and control group.The control group was given conventional therapy,the experimental group on the basis of conventional therapy plus daily growth factor injection with 18 g neural.With the clinical dementia rating（CDR）,Mini Mental State Examination（MMSE） score was used to evaluate the clinical effects,compared the 2 groups of patients before treatment and after treatment（for 4 weeks） to improve the situation of cognitive ability,quality of life,daily life ability.Results： Patients in the observation group CDR,MMSE was superior to the control group,the clinical symptoms improved significantly,the difference was significant（P〈0.05）.Conclusion： Nerve growth factor can significantly improve patients with strategic infarction dementia clinical symptoms and mental state,improve the cognitive function of the patients,improve patient quality of life to a certain extent,has important significance for the prognosis of the patients.
出处
《中国医药导刊》
2015年第8期830-831,834,共3页
Chinese Journal of Medicinal Guide
基金
湖北省武汉市卫计委资助项目(编号:WJ2015MB250)
课题名称:院前院内一体化诊疗模式救治中风患者的临床研究
关键词
神经生长因子
关键部位梗死性痴呆
临床疗效
Nerve growth factor
Strategic infarct dementia
Clinical curative effect
