摘要
目的：探讨甲状腺癌和结节性甲状腺肿术后服用左甲状腺素（优甲乐）两治疗模式对骨密度的影响。方法回顾性分析行甲状腺癌手术（行患侧腺叶切除＋峡部切除＋对侧大部分＋颈VI区淋巴结清扫）及结节性甲状腺肿手术（患侧腺叶切除）患者各40例，每天服用优甲乐平均剂量甲状腺癌为85．2μg，结节性甲状腺肿为36．2μg，分别于术后服用优甲乐6个月或1年后检测骨密度。结果6个月时两组间骨密度差异无统计学意义（P＞0．05），1年时甲状腺癌组（观察组）骨密度为（0．64±0．28）g／m2，低于对照组（t＝2.235，P＝0.03）。与术前相比，对照组骨密度无明显变化，观察组骨密度1年时出现降低（P＜0．05）。结论甲状腺癌术后服用优甲乐内分泌治疗易出现骨密度降低，尤其是1年后，临床工作中需提高警惕，可适量补钙预防。
Objective To investigate the impact of different surgical methods and different doses of euthyrox on bone mineral density.Methods A sample of 40 patients received thyroid cancer operation （excised affected side leaf,aisthmus,most of offside and neck VI lymph node dissection）and 40 patients received nodular goiter operation （excised affected side leaf）were collected,the dose of euthyrox taken in was 85 .2μg in thyroid cancer patients and 36.2μg in nodular goiter patients daily,the bone mineral density 6 month and 1 year after operation was detected. Results There was no difference of BMD between the two group 6 month after operation （P〉0.05）,but BMD of the observation group was （0.64±0.28）g/m2,which was lower than that of control group （t=2.235,P=0.03）.Com-pared with pre-operation,BMD of control group had no change and the observation group appeared drop 1 year after operation.Conclusion Patients received thyroid cancer taking in euthyrox may show BMD reduced,especial 1 year after operation,doctors should be on the alert and supplement calcium appropriately.
出处
《中国基层医药》
CAS
2015年第17期2577-2579,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
甲状腺术式
优甲乐
骨密度
Thyroid surgical method
Euthyrox
Bone mineral density
