摘要
目的 探究在脑膜瘤手术中瑞芬太尼与硝普钠控制性降压的临床效果.方法 选取2012年6月至2013年12月脑膜瘤患者62例,将其随机分为瑞芬太尼组和硝普钠组,分别为A组和B组,两组患者的麻醉诱导和维持方法相同,瑞芬太尼组采用0.1 ～0.52 μg/kg的瑞芬太尼进行控制性降压,硝普钠组给予0.5～3μg/（kg·min）硝普钠加以维持.对比两组患者术中平均动脉压（MAP）、心率（HR）变化.结果 降压之后,两组患者的MAP都达到理想标准,组间比较差异未见统计学意义（P＞0.05）.降压过程中瑞芬太尼组的HR明显低于降压之前（P＜0.05）硝普钠组明高于降压之前（P＜0.05）,两组比较差异有统计学意义（P＜0.05）.瑞芬太尼组患者的失血量明显比硝普钠组减少（P＜0.05）,外科医生对瑞芬太尼组术野满意程度明显高于硝普钠组（P＜0.05）.结论 在异氟烷麻醉作用下采用瑞芬太尼对脑膜瘤患者进行控制性降压,具有安全性高、恢复快的优点,临床效果明显优于硝普钠.
Objective To investigate the clinical effect of remifentanil and nitroprusside induced hypotension in meningioma operation.Methods From June 2012 to December 2013,62 cases of meningioma patients were randomly divided into remifentanil group and sodium nitroprusside group,the induction and maintenance of anesthesia method was conducted the two groups,group A was given 0.1-0.52 μg/kg remifentanil fentanyl to control buck,and group B were given 0.5-3 μ g/（kg · min） sodium nitroprusside maintained.Changes of MAP,HR were compared between the two groups.Results After the the blood pressure was decreased,two groups of patients with MAP have reached the ideal standard,there was no significant difference between the two groups （P 〉 0.05）.HR of group A was significantly lower than that before hypotension（P 〈0.05）,HR in the group B was significantly higher than that before hypotension （P 〈0.05）,the difference between the two groups was significant （P 〈 0.05）.Blood loss in group B was significantly higher than that of group A （P 〈 0.05）,and the operative field surgeon satisfaction in group A was higher than that in group B （P 〈 0.05）.Conclusions Remifentanil induced by isoflurane anesthesia for controlled hypotension of meningioma patients has advantages of high safety and quick recovery,and the clinical effect is better than sodium nitroprussid.
出处
《中国实用医刊》
2015年第18期44-45,共2页
Chinese Journal of Practical Medicine
关键词
瑞芬太尼
脑膜瘤
硝普钠
Remifentanil
Meningioma
Sodium nitroprusside
