摘要
目的观察两节段及以上后路椎体融合术中静注氨甲环酸对失血量控制的作用及其对其它并发症的影响。方法按前瞻性随机对照方法将80例两节段及以上后路椎体融合术病例随机分为两组,A组切皮之前15 min静脉滴注15 mg/kg氨甲环酸,B组不静注氨甲环酸。两组患者的一般资料、失血量及并发症被统计比较。结果因需要其它治疗、失访等其它原因12例被排除,其余68例病人中A组35例,B组33例。两组的一般资料、手术时间、住院天数、术前血液学、术中失血量、并发症比较差异无统计学意义(P>0.05);A组的术后失血量和总血量明显低于B组(P<0.05)。结论两节段及以上后路椎体融合术中注射15 mg/kg氨甲环酸有效减少术后失血,但同时也没有增加肺栓塞、深静脉血栓、死亡等并发症的风险。
Objective The purpose of this study was to evaluate tranexamic acid used during surgery to determine efficacy and associated complications.Methods This study was a randomized prospective analysis of 80 consecutive patients undergoing posterior approach lumbar surgery with more than two segment xation.Patients were divided into two groups：group A received a bolus of 15 mg/kg of intraoperative tranexamic acid 15 minutes before the skin incision;group B did not receive intraoperative tranexamic acid.Patient demographics,blood loss,and complications were recorded.Results 12 patients were excluded due to lost,the need for other therapy.Of the remaining patients,in the tranexamic acid group,postoperative blood loss was signi？cantly lower than that in the control group（P〈0.05）.there were no statistically significant differences in major and minor complications between the two groups.Conclusion In posterior approach lumbar surgery with more than two segment？xation intraoperative tranexamic acid can signi cantly reduce postoperative blood loss,and there were no signi cant side effects.
出处
《内蒙古医学杂志》
2015年第7期810-812,共3页
Inner Mongolia Medical Journal
关键词
氨甲环酸
抗纤维蛋白溶解药
腰椎退变
内固定
出血
tranexamic acid
anti brinolytic drug
degenerative lumbar disease
fixation
blood loss
