摘要
目的探讨自杀行为与5-HT1BR基因rs6298,5-HT2AR基因rs6311、rs6313及5-HT2BR基因rs765458单核苷酸多态性的关联。方法提取中国北方地区281例伴有冲动性自杀行为的抑郁症患者(病例组)和300名健康对照者(对照组)基因组DNA,采用Tap Man探针单核苷酸多态性(SNP)基因分型技术检测病例组及对照组所选位点基因型;统计分析采用χ2检验比较病例组和对照组的基因型和等位基因的分布差异。结果病例组和对照组的5-HT2AR基因rs6311(χ2=20.736,P=0.000)、rs6313(χ2=7.645,P=0.022)基因型频率差异有统计学意义,5-HT1BR基因rs6298、5-HT2BR基因rs765458基因型组差异无统计学意义(P>0.05),5-HT1BR基因rs6298,5-HT2AR基因rs6311、rs6313及5-HT2BR基因rs765458组等位基因频率差异无统计学意义(P>0.05)。结论 5-HT2AR基因rs6311、rs6313位点SNP与自杀行为有明显关联,5-HT1BR基因rs6298、5-HT2BR基因rs765458位点SNP与自杀行为无明显关联。
Objective To explore the associations of single nucleotide polymorphism （SNP） of 5-hydroxytryptamine- 1B receptor （ 5-HT1BR ） gene rs6298, 5-hydroxytryptamine 2A receptor （ 5-HT2AR ） gene rs6311 and rs6313, and 5-hydroxytryptamine 2B receptor（5HT2BR） gene rs765458 with suicidal behavior. Methods The blood samples of 281 de- pression patients with impulsive suicide attempt and 300 age-matched healthy physical examinees were selected in a hospital from November 2012 through March 2014. The DNA of the blood samples was extracted and genoptyped with TapMan SNP genotyping probe. x2 test was adopted in statistical analyses to compare the differences in the distribution of gene alleles between the cases and controls. Results There were significant differences in the genotype frequencies of 5-HT2AR gene rs6311 （X2 = 20. 736, P = 0. 000） and rs6313 （X2 = 7. 645, P = 0. 022 ） between the cases and the controls. No significant differences were observed in genotypes of 5-HT1BR gene rs62985 and 5-HT2BR gene rs765458 and in the allele frequen- cies of 5-HT1BR gene rs6298,5-HT2AR gene rs6311 and rs6313, and 5-HT2BR gene rs765458 between the cases and the controls （all P 〉 0. 05 ）. Conclusion The SNPs of 5-HT2AR gene rs6311 and rs6313 are significantly associated with suicidal behavior,but the SNPs of 5-HT1BR gene rs6298,5-HT2BR gene rs765458 have no significant association with suicidal behavior.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2015年第9期1147-1150,共4页
Chinese Journal of Public Health
基金
国家自然科学基金(81102175)
