摘要
目的探讨体重超标与肿瘤发病风险的相关性。方法对11 513例健康体检者资料进行分析,分性别研究体重指数(BMI)与癌胚抗原(CEA)、甲胎蛋白(AFP)的相关性,并对体重正常组、超重组、肥胖组的CEA超标率、AFP超标率进行统计分析。结果男性BMI与CEA具有相关性(r=0.053,P<0.05),与AFP无相关性(r=0.006,P>0.05);女性BMI与CEA、AFP均具有相关性(r分别为0.192、0.079,P值均<0.01)。男性体重正常组与超标组的CEA超标率差异有统计学意义(χ2=4.49,P<0.05),AFP超标率差异无统计学意义(χ2=0.74,P>0.05);女性体重正常组与超标组的CEA超标率、AFP超标率差异有统计学意义(χ2分别=8.80、4.63;P分别<0.01、0.05)。男性超重组与肥胖组的CEA超标率差异具有显著性(χ2=4.43,P<0.05),AFP超标率差异无统计学意义(χ2=1.79,P>0.05)。女性超重组与肥胖组的CEA超标率、AFP超标率差异均有统计学意义(χ2分别=13.23、6.40;P分别<0.01、0.05)。结论体重超标会增加肿瘤发病风险。男性体重超标与CEA超标具有相关性,与AFP超标不具有相关性;女性体重超标与CEA超标、AFP超标均具有相关性。在预防肿瘤方面,女性应比男性更需注意控制体重。
Objective To explore the correlation between overweight and tumour risk. Methods Data of 11513 cases collected from healthy physical examination were analyzed,The correlation between different genders with body mass index（ BMI）,carcinoembryonic antigen（ CEA）,and alpha fetoprotein（ AFP） was studied. The CEA excessive rate、AFP excessive rate in the normal weight,overweight and obesity groups were statistically analyzed. Results In male,BMI had correlation with CEA（ r = 0. 053,P〈0. 05）,it had no correlation with AFP（ r = 0. 006,P〈0. 05）. While in female,BMI was associated with CEA and AFP（ r = 0.192,0. 079） respectively,p values were 0. 01. The CEA excessive rates in both normal weight group and excessive group（ including overweight and obese） of male showed significant difference（ χ2= 4. 49,P〈0. 05）,while the AFP excessive rate showed no significant difference（ χ2= 0. 74,P〈0. 05）. In female,the CEA excessive rate and AFP excessive rate in both normal weight group and excessive group showed significant difference（ χ2= 8. 80、4. 63 respectively; P〈0. 01、0. 05 respectively）. In male,the CEA excessive group of both excessive weight group and obesity group showed significant difference（ χ2= 4. 43,P〈0. 05）,the AFP excessive rate showed no significant difference（ χ2= 1. 79,P〈0. 05）. While in female,the CEA excessive rate and the AFP excessive rate in both over weight group and obesity group showed significant difference（ χ2= 13. 23、6. 40 respectively; P〈0. 01、0. 05 respectively）. Conclusions Being overweight might increase the risk of tumor. CEA levels were associated with male being overweight,and AFP levels had no correlation. While in female,the overweight group had correlation with the CEA and AFP levels. In terms of tumor prevention,female should pay more attention to weight control.
出处
《公共卫生与预防医学》
2015年第4期43-46,共4页
Journal of Public Health and Preventive Medicine
关键词
体重指数
肿瘤
癌胚抗原
甲胎蛋白
风险评估
Body mass index
Tumor
Carcinoembryonic antigen
Alpha fetoprotein
The risk assessment
