摘要
目的:探讨2型糖尿病(T2DM)患者骨密度下降及其影响因素。方法:选取120例T2DM住院患者作为糖尿病组,同时选取健康体检者60例为正常对照组,测量身高、体重,计算体重指数(BMI),检测糖化血红蛋白,并采用双能X线骨密度仪检测骨密度(BMD),进行统计学分析。结果:糖尿病组患者BMD下降比例明显高于正常对照组;T2DM患者的BMD下降发生率随患者的年龄、糖化血红蛋白(Hb A1C)及BMI的增加而增加;使用二甲双胍和使用胰岛素的T2DM患者BMD下降者较未使用者发生率低,使用噻唑烷二酮的T2DM患者BMD下降者较未使用者发生率高。结论:良好的血糖控制、合理用药能减少T2DM患者骨质疏松的发生。
Objective：To explore the factors affecting bone mineral density mass（ BMD） in patients with type 2 diabetes mellitus（ T2DM）. Methods： One hundred and twenty cases diagnosed with T2 DM were selected as diabetic group,and 60 healthy subjects were involved as normal control group. Height,weight,body mass index（ BMI） and glycosylated hemoglobin were measured and BMD was detected by dual energy X-ray absorptiometry,then they were analyzed statistically. Results： The proportion of decreased BMD were significantly higher in patients with diabetes than that of normal control group. Correlation analysis showed that the incidence of decreased BMD was positively correlated with age,Hb A1 C and BMI in patients with T2 DM,and the incidence of decreased BMD in diabetic groups was lower in patients with treatment of metformin as well as insulin. The incidence of decreased BMD was higher in patients using thiazolidone than those without thiazolidone treatment. Conclusion： Good glycemic control and rational use of drugs can reduce the incidence of osteoporosis in patients with T2 DM.
出处
《内科急危重症杂志》
2015年第4期269-270,273,共3页
Journal of Critical Care In Internal Medicine
关键词
2型糖尿病
骨密度
骨质疏松
Type 2 diabetes mellitus Bone mineral density Osteoporosis
