摘要
目的研究比索洛尔对老年心力衰竭患者血浆脑钠肽(BNP)、血尿酸及心功能的影响。方法选取2011年5月至2014年5月于本院接受治疗的178例老年心力衰竭患者为研究对象,按照治疗方法不同分为对照组(n=74)和观察组(n=104),对照组患者给予抗心力衰竭等常规治疗,观察组患者在对照组基础上口服比索洛尔。比较两组患者治疗前后血浆BNP、血尿酸、心功能各指标水平及临床疗效。结果两组患者治疗前血浆BNP及心功能各指标比较差异均无显著性(P>0.05)。观察组患者治疗后心率(HR)、左心室舒张末期内径(LVEDd)、左心室收缩末期内径(LVESd)、BNP水平均低于对照组,左室射血分数(LVEF)高于对照组(P<0.05)。观察组患者治疗总有效率高于对照组(P<0.05)。结论比索洛尔可有效改善老年心力衰竭患者的心功能,降低血浆BNP水平,安全性较高,值得临床推广应用。
ObjectiveTo research the effects of bisoprolol on plasma brain natriuretic peptide （BNP）, blood uric acid and heart function in elderly patients with heart failure.MethodSelected from May 2011 to May 2014 in our hospital treated 178 cases of elderly heart failure patients for the study. According to the different treatment methods they were divided into control group （n=74） and observation group （n=104）. Control group were treated with conventional anti-heart failure treatment, observation group were treated with bisoprolol on the basis of control group. The plasma BNP, blood uric acid, heart function and clinical efifcacy were compared between the two groups before and after treatment.ResultThere were no signiifcant differences in the BNP and heart function of the two groups before treatment （P〉0.05）. After treatment, heart rate （HR）, left ventricular end diastolic diameter （LVEDd）, left ventricular end systolic diameter （LVESd）, and BNP levels in observation group were lower than control group, left ventricular ejection fraction （LVEF） was higher than control group （P〈0.05）. The total effective rate in observation group was, higher than control group （P〈0.05）.ConclusionBisoprolol can improve heart function in elderly patients with congestive heart failure and decrease plasma BNP levels, higher security, worthy of clinical application.
出处
《中国医学前沿杂志（电子版）》
2015年第6期172-174,共3页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
老年
心力衰竭
脑钠肽
血尿酸
心功能
比索洛尔
Elderly
Heart failure
Brain natriuretic peptide
Blood uric acid
Heart function
Bisoprolol
